Brain ASAP

Age-Related Brain Volume Changes in Men & Women (2024 MRI Study)

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Normal aging leads to a decrease in brain volume, with gray and white matter shrinking and cerebrospinal fluid increasing, as measured by synthetic MRI. Highlights: Study Sample: 300 healthy adults (141 males, median age 48; 159 females, median age 50) were analyzed using synthetic MRI. Brain Volume Trends: Brain parenchymal volume (nBPV) decreases steadily with …

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Genetics of Depression Linked to Gut Microbiome Abnormalities (2024 Study)

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Alterations in the gut microbiome are causally linked to major depressive disorder (MDD), with certain gut bacteria either increasing or decreasing the risk of developing MDD. Highlights: Protective Bacteria: Ten gut bacterial taxa, including phylum Actinobacteria and family Bifidobacteriaceae, were found to be protective against MDD. Risk Factors: Ten other taxa, such as phyla Firmicutes …

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Autism Linked to High Leptin & Low Progranulin in Children (2024 Meta-Analysis)

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Leptin levels are significantly increased in children with autism spectrum disorder (ASD) compared to healthy controls, suggesting a potential role in ASD pathology. Highlights: Leptin Levels: Children with ASD have significantly higher serum leptin levels compared to healthy controls, as confirmed by both individual study results (p=0.0319) and meta-analysis (p<0.001). Progranulin Reduction: In addition to …

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Shexiang Baoxin Pills (SBP) May Reduce Depression & Improve Heart Function via Anti-Inflammatory Effect (2024 Rat Study)

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Shexiang Baoxin Pills (SBP) may help improve heart function and reduce depression in patients with acute myocardial infarction (AMI) by reducing inflammation. Highlights: Depression & Heart Disease Link: Patients with heart attacks often experience depression, which can worsen their heart condition. Study Purpose: This study tested the effectiveness of SBP, a traditional Chinese medicine, in …

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Allopregnanolone vs. Diazepam: Antidepressant Effects via Brain Activity Modulation (2024 Mouse Study)

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Allopregnanolone shows antidepressant-like effects in mice by increasing social interaction and specific brain wave activities, unlike diazepam. Highlights: Allopregnanolone: Allopregnanolone, a neuroactive steroid, increases social interaction time in mice experiencing social defeat stress, indicating potential antidepressant-like effects. Brain Activity: This increase in social interaction is associated with heightened theta and beta oscillations in the basolateral …

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Resocialization After Social Isolation Reverses Neuroinflammation & Depression in Mice (2024 Study)

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Resocialization significantly reduces depressive behaviors in socially isolated mice by decreasing neuroinflammation and nitrite levels in the hippocampus. Highlights: Depressive Behaviors: Resocialization reduced depressive behaviors in socially isolated mice, as shown by improved performance in behavioral tests. Neuroinflammation: Resocialization led to decreased levels of pro-inflammatory genes (IL-1β, TNF, and TLR4) in the hippocampus, indicating reduced …

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Moderate Alcohol Intake Increases Depression Relapse in Men on SNRIs (2024 Study)

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Moderate alcohol intake in men treated with SNRI antidepressants significantly increases the risk of depression relapse, according to a new study. Highlights: Risk Increase with SNRIs: Men with moderate alcohol consumption and elevated liver enzymes are significantly more likely to relapse when treated with serotonin-norepinephrine reuptake inhibitors (SNRIs). Sex Differences: Men generally had higher alcohol …

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Aesthetic Chills (Frisson) May Help Treat Depression: Goosebumps from Emotional Stimuli (2024 Study)

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Experiencing aesthetic chills can positively influence self-related beliefs in people with depression, similar to the effects of psychedelics, suggesting potential as a non-pharmacological intervention. Highlights: Novel Approach: Aesthetic chills, characterized by physical sensations like shivers and goosebumps, may help shift negative cognitive patterns in depression. Study Results: 96 patients with major depressive disorder showed positive …

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Transcranial Alternating Current Stimulation (TACS) for Depression: Effective Adjunct via Reducing Prefrontal Alpha Waves (2024 Trial)

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Adding transcranial alternating current stimulation (tACS) to antidepressant treatment improves depression symptoms more effectively than using antidepressants alone. Highlights: Enhanced Efficacy: tACS combined with antidepressants significantly reduces depression symptoms compared to antidepressant treatment alone. Lasting Effects: The additional antidepressant benefits of tACS persist for at least 4 weeks after treatment ends. Brain Activity Changes: Patients …

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