Neurostimulation

Repeated Neuronal Stimulation Triggered Cyclin B-Linked Nuclear Reprogramming in Mice

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Repeated Neuronal Stimulation Triggered Cyclin B-Linked Nuclear Reprogramming in Mice

TL;DR: A 2026 mouse study in Nature Communications reported that 10 daily bouts of optogenetic dentate-gyrus stimulation produced weeks-long changes in chromatin, nuclear structure, behavior, and spatial coding, while Cyclin B deletion weakened several effects; this ECT-inspired model does not establish how electroconvulsive therapy works in people. Key Findings Ten stimulation sessions produced the durable …

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Depression Reduced Alpha-Beta Reward Signaling in Movement Disorder Patients

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Depression Reduced Alpha-Beta Reward Signaling in Movement Disorder Patients

TL;DR: A 2026 study in eNeuro used intracranial electroencephalography (EEG), a recording method for brain electrical activity, during deep brain stimulation surgery and found that Parkinson’s disease and essential tremor patients with elevated depression symptoms had weaker corticostriatal alpha-beta reward signaling. Key Findings 30 DBS patients participated: The sample included 14 Parkinson’s disease patients and …

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DLPFC rTMS Improved Dual-Task Walking After Subacute Stroke

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DLPFC rTMS Improved Dual-Task Walking After Subacute Stroke

TL;DR: A 2026 randomized trial in Physiotherapy Research International found that adding active 5 Hz repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex to dual-task stroke rehabilitation produced larger gains in Timed Up-and-Go performance, balance confidence, and cognitive screening than sham stimulation plus the same training. Key Findings Small randomized trial: The study …

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DLPFC rTMS Reduced Cigarette Craving: Heavier Baseline Symptoms Marked Responders

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DLPFC rTMS Reduced Cigarette Craving: Heavier Baseline Symptoms Marked Responders

TL;DR: A 2026 medRxiv preprint found that one session of repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) reduced cigarette craving in adults with tobacco use disorder, and the people who responded had heavier baseline smoking, craving, and withdrawal. Key Findings DLPFC craving test: The randomized crossover study included 60 adults …

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Adaptive DBS Reduced Falls in Parkinson’s Gait Feasibility Trial

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Adaptive DBS Reduced Falls in Parkinson's Gait Feasibility Trial

TL;DR: A 2026 randomized feasibility trial in Nature Medicine found that gait-synchronized adaptive deep brain stimulation was feasible and safe in 5 people with Parkinson’s disease, with early findings of improved gait symmetry, lower variability, and fewer reported falls than continuous stimulation. Key Findings 5 Parkinson’s patients: The 1-center feasibility trial enrolled people with Parkinson’s …

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Dentate Nucleus Deep Brain Stimulation Improved Cerebellar Ataxia Symptoms Across 27 Patients in Systematic Review

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Dentate Nucleus Deep Brain Stimulation Improved Cerebellar Ataxia Symptoms Across 27 Patients in Systematic Review

TL;DR: A 2026 systematic review in The Cerebellum found that deep brain stimulation (DBS) produced modest symptom improvement in selected cerebellar ataxia patients, with dentate nucleus stimulation most common in humans and interposed nucleus stimulation emerging from animal studies. Key Findings Dentate nucleus is the dominant human DBS target: Across 15 clinical studies (27 patients), …

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Visual Distraction Strengthened the Oblique Effect in Working Memory

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Visual Distraction Strengthened the Oblique Effect in Working Memory

TL;DR: A 2026 study in Cognitive, Affective, & Behavioral Neuroscience found that visual working memory, the short-term holding of visual details, still showed a strong cardinal-versus-diagonal orientation bias under distraction, while transcranial direct current stimulation (tDCS), a weak noninvasive brain-stimulation method, did not improve task reports. Key Findings Two stimulation experiments tested orientation memory: Researchers …

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tDCS Over rTPJ and lDLPFC Changed Empathy Differently

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tDCS Over rTPJ and lDLPFC Changed Empathy Differently

TL;DR: A 2026 study in Psychological Medicine found that transcranial direct current stimulation (tDCS), a weak electrical brain-stimulation method, affected empathy differently depending on whether researchers targeted the right temporoparietal junction or the left dorsolateral prefrontal cortex. Key Findings Two brain targets diverged: right temporoparietal junction (rTPJ) stimulation strengthened cognitive empathy, while left dorsolateral prefrontal …

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tDCS Plus Cognitive Training Gave Short-Term Cognitive Benefit

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tDCS Plus Cognitive Training Gave Short-Term Cognitive Benefit

TL;DR: A 2026 systematic review posted on medRxiv found that transcranial direct current stimulation (tDCS), a weak noninvasive brain-stimulation method, added to cognitive training produced a small short-term cognitive benefit across 27 trials, but the effect faded at follow-up and the evidence certainty was very low. Key Findings 27 controlled studies: The meta-analysis included 1,012 …

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OCD DBS Response Linked to Lower GPe Alpha-Band Activity

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OCD DBS Response Linked to Lower GPe Alpha-Band Activity

TL;DR: A 2026 preprint in medRxiv found that deep brain stimulation for severe obsessive-compulsive disorder was followed by lower globus pallidus externus alpha-band activity in clinically responsive patients, suggesting a possible brain readout of sustained DBS response. Key Findings 10 severe OCD patients: Researchers recorded local field potentials from the anterior globus pallidus externus (GPe) …

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