Drugs & Medications

Psychoplastogens: Rewiring the Brain via Neuroplasticity with Psychedelics

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Big picture: Psychoplastogens are a groundbreaking new class of psychoactive compounds that rapidly induce structural and functional changes in the brain, allowing pathological neural circuits to be rewired for therapeutic benefit. Key facts about psychoplastogens: Rapidly increase neural plasticity, unlike traditional antidepressants that work slowly. Produce fast-acting and sustained antidepressant effects in humans after a …

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Long-Term Amphetamine Exposure: D2 Dopamine Receptors & Transporters

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Amphetamine is well known for its ability to increase dopamine levels in the brain. But new research suggests the psychostimulant drug may also directly alter dopamine 2 receptors, with implications for behavioral effects and physiological changes seen after chronic amphetamine use. Key facts: In cells expressing the dopamine transporter, prolonged amphetamine exposure decreased dopamine 2 …

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Pharmaceutical Contaminants in Drinking Water: Risks of Chronic Low-Dose Exposures

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Wastewater from pharmaceutical plants and research facilities may contain concerning levels of toxic chemicals and drugs. As this water is often reused for irrigation or finds its way into drinking water, it poses significant public health risks that urgently need addressing. Key Facts: Wastewater can contain residues from thousands of different pharmaceuticals, including antibiotics, antidepressants, …

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Kava Kava: Pacific Roots, Neuropharmacology, Modern Resurgence

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Kava is an ancient ceremonial drink from the Pacific Islands that’s gaining popularity worldwide for its ability to reduce anxiety, improve sleep, and protect brain health. Key facts about kava: Kava comes from the root of the Piper methysticum plant and has been consumed ceremonially and socially in Pacific Island cultures for thousands of years. …

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Pharmacology, Benefits, Risks of Kratom: A Prescription Opioid Alternative

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Kratom is a plant gaining popularity as an alternative painkiller and recreational drug. But how much do we really know about its risks and benefits? About Kratom: Kratom is a tropical tree in the coffee family, native to Southeast Asia. People ingest its leaves to produce stimulant and opioid-like effects. Use is rising in the …

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Semaglutide Reduces Alcohol Drinking in Mice: Potential Addiction Treatment

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The FDA-approved diabetes drug semaglutide reduces alcohol drinking in mice and rats, suggesting it could be repurposed as an effective medication for alcohol use disorder (AUD). Key findings include: Semaglutide dose-dependently decreased binge-like drinking in both male and female mice. In rats, semaglutide reduced binge-like and dependence-induced alcohol drinking. Semaglutide also decreased consumption of caloric …

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Most Effective Drugs for Acute Stress Disorder in Chinese Pilots (According to Medical Experts)

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A panel of Chinese medical experts has reached a consensus on recommended medications for rapidly and effectively treating symptoms of acute stress disorder (ASD) in pilots. The goal is to quickly relieve symptoms and restore cognitive function to ensure flight safety. The experts recommended different medications based on the specific ASD symptoms present. Key Facts: …

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CBD for Athletes: Cannabidiol Benefits for Sports Performance & Recovery

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Cannabidiol (CBD) has recently emerged as a popular supplement among athletes looking to enhance recovery and performance. Key facts about CBD: CBD is a natural compound extracted from cannabis/hemp plants It does not cause psychoactive effects like THC CBD interacts with the body’s endocannabinoid system to produce potential benefits Athletes use CBD hoping to improve …

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Nicotine: Cognitive Enhancement or Normalization of Deficits?

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Smoking remains a major public health issue. Nicotine, the primary addictive component of tobacco, may enhance cognition but also drives continued use. Understanding nicotine’s effects on the brain is key for developing better interventions. Key facts: Nicotine enhances functions like attention, motor skills, and memory but mechanisms remain unclear. Genetic variations predict responses to nicotine’s …

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