Neuropsychiatric Disorders

Psilocybin’s Rapid Anti-Inflammatory Effects (TNF-Alpha, IL-6, CRP) for Depression & Social Benefits

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A new study provides evidence that the psychedelic compound psilocybin has both immediate and lasting anti-inflammatory effects in healthy volunteers. The findings shed light on how psilocybin may improve mood, social behavior, and potentially treat depression. Key facts: Psilocybin decreased the inflammatory marker TNF-alpha immediately after administration. Seven days later, psilocybin reduced two other inflammatory …

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Immune Dysfunction & Neuroinflammation in Autism Spectrum Disorder (ASD)

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Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication deficits and repetitive behaviors. Research increasingly points to dysregulation of the innate immune system and neuroinflammation as contributing factors in ASD. Key facts: Inflammatory cytokines and chemokines are consistently elevated in the blood of individuals with ASD. These suggest activation of the …

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New MRI-Guided Ultrasound Ablative Surgery for Treatment-Resistant OCD

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Obsessive-compulsive disorder (OCD) is a chronic and often debilitating mental illness characterized by intrusive, irrational thoughts and repetitive behaviors. For patients with severe, treatment-resistant OCD, surgical ablation of problematic brain regions may provide lasting relief when other therapies have failed. A novel technique called magnetic resonance-guided focused ultrasound surgery (MRgFUS) is emerging as a promising …

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Tardive Dyskinesia Research Trends: Examining the Past 50 Years

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Tardive dyskinesia (TD) is an involuntary movement disorder caused by long-term use of antipsychotic medications. It involves repetitive, uncontrolled movements of the face, limbs or trunk. TD can be an unrelenting concern for patients and doctors due to its persistent and potentially irreversible nature. Key Facts: Research output on TD peaked in the 1990s, declined …

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New Epilepsy Treatments in Development (2023): Neuromodulation, CBD, Gene Therapy

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Epilepsy impacts millions of people worldwide. While medications have been the mainstay of treatment, one-third of patients continue to have seizures despite available drugs. This highlights the need for innovative therapies. Recent years have seen exciting developments that bring new promise for improved seizure control. Key Facts: Epilepsy is a neurological disorder characterized by recurrent, …

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Depression vs. Anxiety Differences: Brain Waves & Activation Patterns via Machine Learning

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Research provides new evidence that generalized anxiety disorder (GAD) and depressive disorder (DD) have distinct patterns of brain activity. Machine learning analysis of EEG data reveals signature brain features that may enable more accurate diagnosis. Key Facts: DD showed increased beta band power and complexity compared to GAD Brain network connectivity was altered in both …

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Deep Brain Stimulation for OCD: Long-Term Effects & Outcomes

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Deep brain stimulation (DBS) of a brain region called the ventral capsule/ventral striatum (VC/VS) may provide long-term relief for people with severe, treatment-resistant obsessive-compulsive disorder (OCD), according to a new retrospective study. Key findings: 6 out of 9 people with severe OCD achieved remission after DBS surgery It took an average of 14 months for …

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Adrenaline Addiction in Rock Climbers: Thrill Seeking Behavior

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Extreme sports like rock climbing are often described as “addictive” – but is this just a figure of speech or is there scientific evidence that these sports can produce addiction-like behaviors? A new study took a deep dive into this question, examining withdrawal symptoms in rock climbers during periods of abstinence from climbing. Key Facts: …

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Clonidine for Insomnia & Sleep in Chronic Pain Patients: More Effective Than Zopiclone

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A new study published in the Journal of Clinical Sleep Medicine has found that the medication clonidine is more effective and safer than zopiclone for treating insomnia in people with chronic pain. Key findings: Clonidine provided better pain relief than zopiclone. Clonidine helped patients fall asleep faster. Patients felt more rested after taking clonidine compared …

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Modafinil & Serotonin Receptors Influence Gambling Behaviors Like “Loss Chasing”

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Gambling is a complex behavior influenced by multiple factors in the brain. New research in mice provides insight into the neurobiology underlying key aspects of gambling such as making the initial decision to gamble and persistently chasing losses. Key Facts: Mice exhibit typical gambling behaviors like choosing to gamble more when odds of winning are …

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