Seizures Were the Most Common First Sign of PRES Brain Swelling in Children, 20-Year Review Finds

Seizures Were the Most Common First Sign of PRES Brain Swelling in Children, 20-Year Review Finds

TL;DR: At a leading London children’s hospital, 77 children with PRES, a sudden brain-swelling syndrome, were reviewed over 20 years. Nearly 4 in 5 first showed up with seizures, almost all had another serious illness, and about a third of those given seizure medicine still needed it after 6 months. Key Findings Seizures came first: …

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Seizures That Steal Speech Can Mimic a Stroke

Seizures That Steal Speech Can Mimic a Stroke

TL;DR: Seizures can sometimes steal a person’s ability to speak or understand language for hours or days without causing convulsions, and they can look just like a stroke. A review of 87 reported patients found that 1 in 5 attacks left lasting language problems, often after treatment was delayed. Key Findings 87 patients, 92 attacks: …

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Woman Seizure-Free After Brain Cyst Surgery

Woman Seizure-Free After Brain Cyst Surgery

TL;DR: A 35-year-old woman with 20 years of seizures that medicines could not control became seizure-free after surgery removed a small fluid-filled cyst and the nearby part of her brain where seizures started. It is one case, so it cannot prove the cyst caused her epilepsy. Key Findings Seizures since age 15: Up to 2 …

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Diabetes Before Pregnancy Linked to Higher Epilepsy Risk in Children

Diabetes Before Pregnancy Linked to Higher Epilepsy Risk in Children

TL;DR: In 3 large birth studies covering 5.3 million children, kids whose mothers had type 1 or type 2 diabetes before pregnancy were about a third more likely to develop epilepsy. Diabetes that first appears during pregnancy showed no clear link, and none of this proves diabetes is the cause. Key Findings 3 studies, 5.3 …

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FMR1 Gene Therapy Reduced Seizures and Gamma EEG Power in Fragile X Mice

FMR1 Gene Therapy Reduced Seizures and Gamma EEG Power in Fragile X Mice

TL;DR: A 2026 mouse study in Gene Therapy used an adeno-associated virus 9 (AAV9) vector to deliver human FMR1 and reduced sound-triggered seizures, excessive digging, and gamma-frequency electroencephalography (EEG) power in selected dose and route groups. The outcomes came from separate experiments, and high-dose intravenous treatment without immunosuppression caused excess deaths. Key Findings Adolescent seizure …

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Hemispheric Asymmetry MRI Model Classified Focal Cortical Dysplasia in Epilepsy

Hemispheric Asymmetry MRI Model Classified Focal Cortical Dysplasia in Epilepsy

TL;DR: A 2026 preprint in medRxiv tested an interpretable machine-learning model for focal cortical dysplasia (FCD), a lesion linked to drug-resistant epilepsy, and found that hemispheric-asymmetry MRI features classified 39 of 50 subjects correctly in leave-one-out testing. Key Findings 50-subject MRI sample: The analysis used 25 FCD patients and 25 age-matched healthy controls from the …

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Ketogenic Diet Therapies Reduced Seizures in Drug-Resistant Epilepsy Review

Ketogenic Diet Therapies Reduced Seizures in Drug-Resistant Epilepsy Review

TL;DR: A 2026 systematic review in PLOS One found that ketogenic diet therapies were linked to more 50% seizure reductions in drug-resistant epilepsy, with clearer evidence in children and more uncertainty for near-complete seizure control, side effects, adherence, and quality of life. Key Findings 17 randomized trials were included: The review screened 1,193 records after …

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DBS Electrodes Improved Deep Brain EEG Source Localization Accuracy

DBS Electrodes Improved Deep Brain EEG Source Localization Accuracy

TL;DR: A 2026 study in Journal of Neural Engineering reported that adding passive recordings from bidirectional deep brain stimulation (DBS) electrodes to scalp electroencephalography (EEG) improved simulated deep-brain source localization, especially near the implanted lead. Key Findings 72-channel scalp EEG: The simulations combined scalp EEG with 4-contact, 8-contact, or 40-contact DBS electrode configurations. Three noise …

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Parahippocampal Herniation on MRI Mimicked Emergency Brain Disease

Parahippocampal Herniation on MRI Mimicked Emergency Brain Disease

TL;DR: A 2026 study in Radiology Case Reports described a 14-year-old boy whose seizure workup found a rare congenital left parahippocampal herniation on MRI, with imaging features that favored a benign developmental variant rather than tumor or acute brain herniation. Key Findings One adolescent case: The report involved a previously healthy 14-year-old boy evaluated after …

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