Dentate Gyrus Added 385,000 Granule Neurons Despite Neuron Turnover

Dentate Gyrus Added 385,000 Granule Neurons Despite Neuron Turnover

TL;DR: A 2026 rat study in Hippocampus found that the dentate gyrus (DG), a hippocampal memory region, gained about 385,000 granule neurons from 2 to 18 months of age even though older development-born neurons were also being lost. Key Findings 385,000-cell net gain: Total DG granule neuron counts increased by about 385,000 cells from 2 …

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Immature Hippocampal Neurons Marked Cognitive Resilience in Alzheimer’s Brains

Immature Neurons Linked to Alzheimer’s Resilience

Immature Neurons Linked to Alzheimer’s Resilience TL;DR: A 2026 Cell Stem Cell study used single-nucleus RNA sequencing of aged human hippocampus tissue and found rare immature neurons in healthy, Alzheimer’s, and dementia-resilient brains. The important signal was not simply whether these cells existed. It was how their gene activity changed in Alzheimer’s disease and in …

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