Masitinib ALS Follow-Up Reported Higher 5-Year Survival

Masitinib ALS Follow-Up Reported Higher 5-Year Survival

TL;DR: A 2026 medRxiv preprint reanalyzed long-term survivors from the AB10015 ALS trial and reported that masitinib-treated patients had higher 5-year survival than historical benchmarks, but the analysis was post hoc, sponsor-supported, and lacked long-term placebo follow-up. Key Findings Five-year survival was 42.3%: 55 of 130 patients assigned to masitinib 4.5 mg/kg/day were alive at …

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White Matter Hyperintensities Tracked ALS Progression and Survival

White Matter Hyperintensities Tracked ALS Progression and Survival

TL;DR: A 2026 medRxiv preprint found that white matter hyperintensity (WMH) burden, the amount of MRI-visible white-matter injury, was greater and progressed faster in amyotrophic lateral sclerosis (ALS), with progression tied to worse motor and cognitive scores. Key Findings 369-person MRI sample: Researchers analyzed 204 ALS patients and 165 healthy controls from the Canadian ALS …

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