EXPLORE THE SCIENCE
TL;DR: A 2026 medRxiv preprint found that soluble CD27 (sCD27), a T-cell activation marker, was elevated in a subgroup of patients with severe psychiatric disorders and was more common when autoimmune disease or abnormal cerebrospinal fluid (CSF) inflammation…
Read article
TL;DR: A 2026 systematic review and meta-analysis in Molecular Neurobiology found that plasma phosphorylated tau 217 (p-tau217), a blood marker of Alzheimer-linked tau pathology, identified biomarker-defined Alzheimer’s disease with pooled sensitivity of 85.4%…
Read article
Blood GFAP Started Mirroring the Brain Only After the BBB Leaked TL;DR: Blood biomarkers mostly failed to mirror the brain while the blood-brain barrier stayed intact; once the barrier leaked, glial fibrillary acidic protein (GFAP), an astrocyte injury protein…
Read article
C4A Broke Away From C1Q in First-Episode Psychosis TL;DR: In cerebrospinal fluid from people with first-episode psychosis, the usual positive relationship between C4A and C1Q disappeared, while C4A’s broader immune-network pattern shifted sharply in a way C4B…
Read article