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late-life depression

DepressionJuly 10, 2026

Ketamine EEG Alpha Redundancy Tracked Depression Response in Late-Life TRD

TL;DR: A 2026 study in Translational Psychiatry found that ketamine changed EEG-derived high-order brain interactions in late-life treatment-resistant depression, and a 24-hour increase in alpha-band redundancy tracked greater depression improvement by Day 7.…

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Brain AgingJune 24, 2026

Depressive Symptoms Accelerated Four Years Before Death in Twin Consortium

TL;DR: A 2025 study in Psychological Science found that depressive symptoms accelerated about 4 years before death in a multinational twin consortium, suggesting that late-life mood worsening can partly reflect terminal decline rather than chronological age al…

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Ketamine EEG Alpha Redundancy Tracked Depression Response in Late-Life TRD

Depressive Symptoms Accelerated Four Years Before Death in Twin Consortium

The findings. The context. The caveats.