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TL;DR: A 2026 mouse study in Neuron found that exercise activates ventromedial hypothalamic SF1 neurons, and that this brain response is required for normal endurance gains after training. Key Findings VMH SF1 neurons: Exercise increased activity-linked Bdnf e…
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CYP2C19 poor metabolizers showed a nominally higher antidepressant remission rate compared to normal metabolizers, but overall genetic variations in CYP2C19 and CYP2D6 were not significantly associated with antidepressant response. Highlights: Higher Remission…
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Researchers have made strides towards enabling personalized dosing for the commonly prescribed antidepressant escitalopram. Using robust clinical trial data, they developed an innovative population pharmacokinetics model that elucidates the impact of patient g…
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Synthetic cathinones like MDPV emerged as drugs of abuse in the early 2010s, gaining notoriety for their powerful stimulant effects and association with bizarre intoxication and death. Despite legislation banning MDPV and its analogs, these substances continue…
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Researchers have uncovered novel details about a specific population of brain cells that regulate obesity. Their findings provide increased understanding of the intricate neural circuits controlling energy balance and point to potential new therapeutic targets…
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