Poly-GR Increased Ferroptosis Vulnerability in C9orf72-ALS Cells
TL;DR: A 2026 study in Cell & Bioscience found that poly-GR, a toxic repeat protein linked to C9orf72-ALS, pushed motor neuron-like cells toward ferroptosis by raising lipid peroxidation and ferrous iron while weakening the Nrf2/Slc7a11 antioxidant pathway. Key Findings GR50 model: Researchers expressed EGFP-GR50, a 50-repeat glycine-arginine poly-GR construct, in NSC-34 motor neuron-like cells. Ferroptosis …
