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TL;DR: In 149 people with memory problems or dementia, blood levels of some brain markers tracked spinal fluid levels well, but others did not match at all. Two common measures of a leaky blood-brain barrier also did not agree with each other. Key Findings Blo…
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TL;DR: In 792 people with stable multiple sclerosis, a blood marker of nerve damage more often placed them in an older age band than their actual age, compared with 302 people without MS. The gap was larger in people with more disability or progressive MS, but…
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TL;DR: A 2026 preprint on medRxiv found that blood tau markers and neurofilament light tracked different parts of amyotrophic lateral sclerosis (ALS), with tau markers linked more to current lower-motor-neuron and muscle-injury features while neurofilament lig…
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Blood GFAP Started Mirroring the Brain Only After the BBB Leaked TL;DR: Blood biomarkers mostly failed to mirror the brain while the blood-brain barrier stayed intact; once the barrier leaked, glial fibrillary acidic protein (GFAP), an astrocyte injury protein…
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