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TL;DR: Across 55 trials in low- and middle-income countries (5,041 adults), people who got therapy had much lower PTSD symptoms than people on a wait-list or other comparison. The evidence was very low certainty because many trials were weakly run. Key Finding…
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TL;DR: A 2026 retrospective database study in Archives of Orthopaedic and Trauma Surgery found that people with major upper-extremity amputations had higher one-year rates of new mental-health diagnoses, antidepressant starts, and psychotherapy use than matche…
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TL;DR: A 2026 study in JAMA Network Open found that a therapy built to restore reward and positive emotion outperformed a matched negative-affect therapy for adults with depression, anxiety, and severely low positive affect. Key Findings PAT beat the matched t…
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Minor or subthreshold depression causes significant suffering and impairment, despite falling short of a major depression diagnosis. Effective early treatment is crucial to alleviate symptoms, improve functioning, and prevent progression to major depression. B…
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Borderline personality disorder (BPD) is a serious and complex psychiatric illness impacting 1-2% of the general population. Despite available treatments, many patients continue to struggle with suicidal behavior, emotional dysregulation, and impaired interper…
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Major depressive disorder (depression) is very common. It causes a lot of suffering and disability around the world. The good news is many people get better with medication, psychotherapy (talk therapy), or both. But for some people, depression just won’t go a…
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A new study published in the journal Mædica – a Journal of Clinical Medicine compared the antidepressant effects of modafinil versus citalopram for treating major depressive disorder (MDD). The medications were equally effective at reducing depressive symptoms…
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