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TL;DR: A 2026 pooled analysis in CNS Drugs combined two six-week trials of adults whose depression hadn’t responded well enough to an antidepressant. Adding the antipsychotic lumateperone instead of a placebo raised the share of people with side effects from 4…
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TL;DR: A 2026 study in Annals of General Psychiatry found that, among 457 adults with recurrent major depressive disorder in Pakistan, escitalopram was the most common single antidepressant and reported side effects varied sharply by drug class. Key Findings C…
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Probiotics may help improve sexual function and reduce depression severity in women treated with SSRIs. Highlights: Depression Prevalence: Approximately 5% of all adults will experience depressive disorder, often accompanied by reduced sexual desire and dysfun…
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Depression is highly prevalent in older adults and those with cardiovascular disease. Selective serotonin reuptake inhibitors (SSRIs) are generally safe first-line treatments, but many wonder if they’re safe for those with cardiovascular disease. Key Facts: Th…
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Energy drinks are beverages that contain ingredients such as caffeine, taurine, and herbal extracts designed to provide mental and physical stimulation. Their popularity and consumption have grown exponentially in recent years, especially among young people. H…
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Insomnia is a highly prevalent sleep disorder affecting up to 35% of the general population – and can significantly impair quality of life. Researchers have been investigating new non-pharmacological treatment options like transcranial electric stimulation (TE…
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Ibogaine, an alkaloid derived from the Tabernanthe iboga shrub found in Africa, has received attention as a potential treatment for addiction, particularly opioid use disorder. While small studies have hinted at effectiveness, a new clinical study shows ibogai…
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Aspartame is an artificial sweetener found in over 6,000 food products. While it provides a sweet taste without calories, emerging research suggests aspartame may negatively impact brain health and function. Key Facts: Aspartame is made up of phenylalanine, as…
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The novel combination drug dextromethorphan-bupropion (Auvelity) was recently approved by the FDA as an oral antidepressant that works rapidly to treat major depressive disorder in adults. This new medication represents an exciting development for depression t…
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Depression affects over 300 million people globally. Current treatments have limited efficacy for many patients. Exciting new research highlights the potential of allopregnanolone agonists like brexanolone and zuranolone as more targeted, rapid-acting antidepr…
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