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Focused Ultrasound Reprogrammed Microglia in Alzheimer’s Rats

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How Focused Ultrasound Reprogrammed Microglia in Alzheimer's Rats

TL;DR: A 2026 bioRxiv preprint found that repeated focused ultrasound changed blood-brain-barrier and microglial biology in Alzheimer’s rats without clearly improving pathology on its own. Key Findings Day 7 after 4 weekly sessions: Aβ42 and pTau231 went the wrong way: Aggregated Aβ42 rose (p = 0.0059), pTau231 rose (p = 0.0009). Repeated barrier opening alone …

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Alzheimer’s Treatment Needs More Than Amyloid Drugs

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Alzheimer's Treatment Needs More Than Amyloid

TL;DR: A 2026 review in Science China Life Sciences argued that Alzheimer’s treatment is moving toward biomarker-guided combinations that address amyloid, tau, APOE, immune state, vascular health, and aging biology. Key Findings Slowing decline is not restoring it: Amyloid antibodies modestly slow progression in early disease but do not reverse cognition — the gap that …

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