visceral pain

Early-Life Visceral Stress Sensitized Auditory Brainstem and Altered Cochlear Proteome in Rat IBS Model

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Early-Life Visceral Stress Sensitized Auditory Brainstem and Altered Cochlear Proteome in Rat IBS Model

TL;DR: A 2026 rat study in Neurobiology of Stress found that early-life visceral stress produced adult IBS-like symptoms alongside auditory brainstem sensitization and cochlear protein changes, giving a mechanistic explanation for sound sensitivity reported by some IBS patients. Key Findings Early-life visceral stress sensitized the auditory brainstem: Rats exposed to early-life visceral stress (the standard …

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Early Life Stress Rewired Gut Nerves and Visceral Pain Pathways

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Early Stress Rewired the Gut's Nerves, Not Just the Brain

Early Stress Rewired the Gut’s Nerves, Not Just the Brain TL;DR: Early life stress produced lasting gut pain and motility changes through enteric and sympathetic nerve pathways, with pediatric cohort data pointing in the same direction. Key Findings Maternal separation produced gut hypersensitivity: The mouse model developed visceral pain sensitivity and lasting motility defects. Motility …

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