Self-Localized Pencil Beam Improved 3D Multiphoton BBB Imaging
TL;DR: A 2026 Nature Methods paper described a self-localized ultrafast pencil beam that made volumetric multiphoton imaging faster and more stable, including 1-minute 3D scans of transferrin uptake in a live human blood-brain barrier model. Key Findings Optics advance: A standard multimode fiber produced a stable, sidelobe-suppressed Bessel-like pencil beam near critical power. Microscopy fit: …
