Dementia

Urine Beta-Amyloid Test Kit Flagged MCI/Alzheimer Disease in Chinese Screening Study

July 9, 2026July 2, 2026 by BrainASAP

TL;DR: A 2026 preprint in medRxiv reported that a urine beta-amyloid protein test kit separated mild cognitive impairment or Alzheimer’s disease from healthy controls in a multicenter Chinese sample, while a 51,187-person community screen showed age-related positive rates. Key Findings 898-person validation sample: The multicenter case-control arm included 266 healthy controls, 167 people with mild …

Trichostatin A Alzheimer’s Screen Flagged 8 Core Genes but Weak Direct Binding

July 1, 2026 by BrainASAP

TL;DR: A 2026 computational study in PLOS One used GEO Alzheimer’s datasets, 130 machine-learning models, and molecular simulations to identify eight candidate genes that may sit in a trichostatin A-related Alzheimer’s disease network. Key Findings 949 predicted TSA targets: The analysis started with predicted human protein targets for trichostatin A, a histone deacetylase inhibitor. Five …

Resting Facial Expressions Differed in Older Adults With MCI-Level Scores

July 1, 2026 by BrainASAP

TL;DR: A 2026 preprint on medRxiv found that older adults with mild-cognitive-impairment-level scores showed different resting facial action patterns than healthy controls, especially upper lip raiser, lip tightener, and lip suck measures. Key Findings MCI-level comparison: The study included 45 older adults and compared 31 participants in the MCI-level group with 14 healthy controls. MoCA-defined …

iSupport-Malaysia Dementia Caregiver Platform Scored Above Usability Benchmark

June 28, 2026 by BrainASAP

TL;DR: A 2026 preprint posted on medRxiv found that iSupport-Malaysia, a culturally adapted multimedia dementia-caregiver platform, scored above the usual usability benchmark and was viewed as culturally appropriate by caregivers and healthcare professionals. Key Findings Four-phase adaptation: The WHO iSupport dementia program was translated into Bahasa Malaysia, culturally adapted, and rebuilt as multimedia e-learning. 23 …

Inhaled CBD Reduced IDO and cGAS Neuroinflammation Signals in Alzheimer Mice

July 9, 2026June 28, 2026 by BrainASAP

TL;DR: A 2025 mouse study in eNeuro reported that inhaled cannabidiol reduced IDO and cGAS pathway activity and lowered pro-inflammatory cytokines in male 5XFAD Alzheimer’s model mice. Key Findings 5XFAD model: The study used male 5XFAD transgenic mice, a common amyloid-heavy Alzheimer’s disease model. Inhaled CBD: Cannabidiol was administered by inhalation rather than by oral …

Amyloid, Tau, and Neurodegeneration Axes Mapped Alzheimer’s Heterogeneity

June 27, 2026 by BrainASAP

TL;DR: A 2026 preprint in medRxiv used amyloid positron-emission tomography, tau molecular imaging, and structural MRI to build individualized Alzheimer’s disease biomarker axes from ADNI and validate them in OASIS. Key Findings 12,430 ADNI images: The pipeline harmonized longitudinal amyloid-beta and tau positron-emission tomography images plus T1 MRI gray matter images from ADNI. 4,958 OASIS …

AI Identified CgA-KO/PS19 Mouse Model of Asymptomatic Alzheimer’s Resilience

June 26, 2026 by BrainASAP

TL;DR: A 2026 study in Acta Neuropathologica Communications used Boolean-network AI analysis of Alzheimer’s RNA-seq data to identify a 40-gene disease signature and validate CgA-KO/PS19 mice as a model of asymptomatic Alzheimer’s-like resilience. Key Findings 289-person training set: Boolean Network Explorer was trained on cortical RNA-seq data from 70 cognitively normal controls and 219 Alzheimer’s …

Blood miRNAs Linked to Hippocampal Volume and Brain Atrophy

June 25, 2026 by BrainASAP

TL;DR: A 2026 Molecular Psychiatry study linked blood-derived microRNAs, short RNA regulators that help control gene expression, to left hippocampal volume and later brain atrophy in adults from the Rhineland Study. Key Findings Baseline MRI cohort: Researchers compared blood microRNA expression in 2,062 adults with baseline MRI measures of left and right hippocampal volume, hippocampal …

REDDI MEG AI Classified Four Neurodegenerative Diseases With 0.81 Balanced Accuracy

June 22, 2026 by BrainASAP

TL;DR: A 2026 preprint in medRxiv reported that REDDI, an interpretable AI pipeline using resting-state magnetoencephalography (MEG), classified four neurodegenerative diseases with mean balanced accuracy of 0.81. Key Findings The dataset covered four disease groups: it included 32 people with mild cognitive impairment, 18 with multiple sclerosis, 20 with Parkinson’s disease, and 39 with amyotrophic …

Rostral Prefrontal Gradient Predicted Creativity in Frontotemporal Dementia

June 22, 2026 by BrainASAP

TL;DR: A 2026 study in Brain found that creativity in behavioral variant frontotemporal dementia tracked a rostral prefrontal cortex gradient, meaning the functional separation between default-mode and executive-control networks predicted creative performance. Key Findings 56-person clinical sample: researchers compared 27 patients with behavioral variant frontotemporal dementia (bvFTD) against 29 control participants from the ECOCAPTURE cohort. …

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