TL;DR: A 2026 Molecular Psychiatry study tested Regional Vulnerability Index for Alzheimer’s disease (RVI-AD), a structural-MRI score of how closely a person’s brain pattern resembles amyloid-positive Alzheimer’s disease, and found that higher RVI-AD predicted conversion from mild cognitive impairment to dementia most strongly in the first 3 years. Key Findings 571-person reference map: Researchers built …
TL;DR: A 2026 study in Alzheimer’s & Dementia: Translational Research & Clinical Interventions used lecanemab pharmacokinetic/pharmacodynamic modeling in early Alzheimer’s disease and found that blood biomarkers worsened after treatment stopped, while monthly maintenance dosing after 18 months was predicted to preserve most p-tau181 and GFAP, an astrocyte-inflammation protein. Key Findings Three plasma biomarkers improved: Lecanemab …
TL;DR: A 2026 descriptive study in JMIR Formative Research reported that the NYUCI-ES dementia-caregiver program required 24 documented cultural adaptations before and during delivery to Chinese and Korean American caregivers. Key Findings 24 adaptation strategies: Researchers identified 24 major changes to the dementia-caregiver intervention. Five adaptation elements: Changes were grouped into content, context, relationship fidelity, …
TL;DR: A 2026 narrative review in the Japanese Journal of Radiology reported that Alzheimer’s brain positron emission tomography (PET) imaging has shifted from supportive diagnosis toward treatment selection because amyloid PET is now central to confirming eligibility for anti-amyloid antibody therapy. Key Findings Three PET roles: The review separated FDG-PET, amyloid PET, and tau PET …
TL;DR: A 2026 medRxiv preprint applied ChatGPT-4o-assisted Bayesian-frequentist hybrid inference to Alzheimer’s single-nucleus RNA-seq data and identified gamma-secretase and HP1 transcription pathways that a no-evidence frequentist setting did not recover. Key Findings 427 ROSMAP samples: The application used postmortem prefrontal cortex single-nucleus RNA-seq data from 427 Religious Orders Study and Memory and Aging Project samples. …
TL;DR: A 2026 preprint in medRxiv found that under-mattress sleep sensors associated lower nighttime respiratory rate and more unstable nighttime movement with higher odds of next-day agitation in dementia, while the same features did not predict how severe agitation became once it occurred. Key Findings 55 dementia patients supplied the main dataset: Researchers matched 333 …
TL;DR: A 2026 study in BMC Psychiatry used Taiwan insurance records to find that dementia in people with schizophrenia was tied more strongly to age and linked medical comorbidities than to antipsychotic exposure after multivariable adjustment. Key Findings 147 dementia cases: Researchers compared 147 people with schizophrenia who developed dementia with 882 sex- and diagnosis-year-matched …
TL;DR: A 2026 medRxiv preprint found that older adults with Montreal Cognitive Assessment (MoCA)-defined mild cognitive impairment had less coordinated pulse-wave responses during a cognitive challenge than cognitively intact older adults. Key Findings Community cognitive-aging sample: The southern Taiwan dataset included 101 older adults: 12 reference participants, 50 people in a MoCA-defined mild cognitive impairment …
TL;DR: A 2026 systematic review and meta-analysis in Psychogeriatrics linked loneliness with Alzheimer’s disease and several forms of suicidal behavior, with especially strong shared correlations for hopelessness, insomnia, entrapment, and stress. Key Findings 316 studies reviewed: Researchers found 44 studies on loneliness and Alzheimer’s disease, 261 on loneliness and suicide, and no original study that …
TL;DR: A 2026 preprint on medRxiv used resting-state functional MRI (fMRI), a brain-connectivity scan taken while people are not doing a task, to divide older adults at Alzheimer’s risk into anxiety biotypes that responded differently to frontal-lobe tDCS stimulation. Key Findings Older-adult tDCS trial: The final sample included 199 older adults, with 99 sham tDCS …
