TL;DR: A 2026 systematic review in The British Journal of Psychiatry linked schizophrenia to a multisystem advanced-aging phenotype, including older-appearing brain scans, shorter telomeres, inflammation, and higher dementia risk. Key Findings 170 studies included: The review synthesized studies of aging markers in schizophrenia and non-affective psychosis published after 2009. Most studies were moderate or high …
TL;DR: A 2026 meta-analysis in Psychological Medicine found postpartum depression (PPD) brain-activity differences across default-mode, limbic, and sensorimotor regions, with spatial overlap in serotonin, dopamine, and vesicular acetylcholine transporter maps. Key Findings 12 imaging studies pooled: The meta-analysis included 475 postpartum depression patients and 504 healthy controls. Higher activity appeared in two regions: PPD was …
TL;DR: Across 4,000+ people, the relationship between brain activity and cognitive control flipped direction depending on whether researchers compared people to each other or tracked the same person over time. The finding is called nonergodicity — and it means decades of group-level brain studies may have been telling us the opposite of what’s true inside …
TL;DR: A 2026 review in BMC Psychiatry found 441 primary MRI and electroencephalogram (EEG), a scalp recording of brain electrical activity, mental-health biomarker studies, but most were small, cross-sectional, and concentrated in depression, making routine clinical use premature. Key Findings 58,824 records screened: Researchers searched MEDLINE and Embase from 2010 to September 2023, then mapped …
TL;DR: A 2022 study in Nature Communications used non-contrast 3D T2-FLAIR MRI, a scan that suppresses ordinary cerebrospinal-fluid brightness, to map possible brain-border drainage routes toward cervical lymph nodes, but FLAIR brightness alone does not prove lymph flow. Key Findings 81 clinical MRI scans supplied the human map: The retrospective cohort included 45 females and …
TL;DR: A 2025 systematic review in Translational Psychiatry found that substance use disorder was associated with recurring resting-state functional MRI (rs-fMRI), a scan of spontaneous brain-network communication, abnormalities in reward and self-control circuits across 53 studies. Key Findings 53-study meta-analysis: Researchers pooled whole-brain rs-fMRI studies covering 1,700 people with substance use disorder and 1,792 healthy …
TL;DR: A 2026 medRxiv preprint on schizophrenia reported that illness insight tracked with resting-state functional MRI (fMRI) flexibility, a measure of how dynamically brain regions reconfigure their connectivity, and that these brain-dynamics patterns aligned with dopamine D2 and serotonin 5-HT2A receptor maps after accounting for antipsychotic receptor occupancy. Key Findings Two insight subtypes: Clinical clustering …
TL;DR: A 2026 systematic review and meta-analysis in Molecular Neurobiology found that plasma phosphorylated tau 217 (p-tau217), a blood marker of Alzheimer-linked tau pathology, identified biomarker-defined Alzheimer’s disease with pooled sensitivity of 85.4% and specificity of 88.0% across 27 studies. Key Findings 27-study evidence base: Researchers analyzed 19,652 participants from studies that compared plasma p-tau217 …
TL;DR: A 2026 study in Science of the Total Environment followed nearly 295,000 Southern California births and linked extreme nighttime heat in early and late pregnancy to higher autism diagnosis by age 5, while daytime heat was not associated. Key Findings A large Southern California cohort anchored the estimate: The retrospective Kaiser Permanente Southern California …
TL;DR: A 2026 medRxiv preprint tested SimulAD, an Alzheimer’s disease progression simulator, and reported that it reproduced mean amyloid-clearance results within 5% error across six major phase III anti-amyloid trials while also separating positive trials from null trials in retrospective power analyses. Key Findings Six phase III trials: Researchers retrospectively simulated TRAILBLAZER-ALZ2, CLARITY AD, EMERGE, …
