Angiopep NK Vesicles Delivered Temozolomide in Glioblastoma Mice

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Angiopep NK Vesicles Delivered Temozolomide in Glioblastoma Mice

TL;DR: A 2026 study in Journal of Nanobiotechnology found that Angiopep-2-modified natural killer cell extracellular vesicles carried temozolomide across glioblastoma barriers, reduced mouse tumor bioluminescence, and extended median survival in an orthotopic GBM model. Key Findings 2.5-3.2x uptake: Angiopep-2 modification increased glioblastoma-cell uptake of NK extracellular vesicles compared with unmodified NK-EV. 2.8-3.5x BBB transport: Ang-NK-EV@TMZ …

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Amyloid, Tau, and Neurodegeneration Axes Mapped Alzheimer’s Heterogeneity

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Amyloid, Tau, and Neurodegeneration Axes Mapped Alzheimer's Heterogeneity

TL;DR: A 2026 preprint in medRxiv used amyloid positron-emission tomography, tau molecular imaging, and structural MRI to build individualized Alzheimer’s disease biomarker axes from ADNI and validate them in OASIS. Key Findings 12,430 ADNI images: The pipeline harmonized longitudinal amyloid-beta and tau positron-emission tomography images plus T1 MRI gray matter images from ADNI. 4,958 OASIS …

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Laypeople Named More Alcohol Than Cannabis Intoxication Cues

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Laypeople Named More Alcohol Than Cannabis Intoxication Cues

TL;DR: A 2026 study in Drug and Alcohol Review found that laypeople reported more and better-developed cues for alcohol intoxication than cannabis intoxication, even though most coded cues for both substances were accurate. Key Findings Intoxication-cue sample: The survey sample was 77.7% female, with an average age of 20.5 years, and came from undergraduate psychology …

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AI Remote Monitoring Studies Favored Parkinson’s but Had High Bias Risk

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AI Remote Monitoring Studies Favored Parkinson's but Had High Bias Risk

TL;DR: A 2026 systematic review in BMC Medical Informatics and Decision Making found that AI models using remote-monitoring data were most often studied in Parkinson’s disease, but 56 of 76 prospective studies had high risk of bias. Key Findings 6,668 records were screened: Researchers narrowed the search to 76 prospective studies of machine learning for …

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Five Adolescent Emotion-Regulation Profiles Tracked Mental Health

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Five Adolescent Emotion-Regulation Profiles Tracked Mental Health

TL;DR: A 2026 study in Research on Child and Adolescent Psychopathology followed 951 New Zealand adolescents and found that 5 emotion-regulation profiles tracked different patterns of anxiety, depression, optimism, resilience, and wellbeing over 5 months. Key Findings 951 adolescents were studied: The sample completed the Process of Emotion Regulation Measure (PERM), a tool that separates …

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ADAS-Cog-13 Flagged Cognitive Impairment in Older Adults With Focal Epilepsy

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ADAS-Cog-13 Flagged Cognitive Impairment in Older Adults With Focal Epilepsy

TL;DR: A 2026 preprint in medRxiv found that the ADAS-Cog-13 cognitive scale detected impairment in older adults with focal epilepsy, but a cutoff of 15 had only modest diagnostic accuracy against an epilepsy-specific neuropsychological standard. Key Findings 83 epilepsy patients: The study analyzed adults older than 55 with focal epilepsy from the Brain, Aging, and …

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PF-04995274 5-HT4 Agonist Changed Depression Signals Without SSRI-Like Bias Shift

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PF-04995274 5-HT4 Agonist Changed Depression Signals Without SSRI-Like Bias Shift

TL;DR: A 2026 randomized study in The British Journal of Psychiatry found that the experimental 5-HT4 receptor agonist PF-04995274 did not mimic citalopram’s early emotional-bias effects in unmedicated depression, but it was linked with lower depression ratings and increased medial-frontal brain activation after about 1 week. Key Findings 90 randomized adults: The RESTAND study assigned …

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5-10 mg THC Did Not Broadly Reduce Stress-Memory Responses

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5-10 mg THC Did Not Broadly Reduce Stress-Memory Responses

TL;DR: A 2026 study in Psychopharmacology found that low oral THC doses did not meaningfully reduce most subjective or physiological responses when healthy adults retrieved memories of a prior social stress task. Key Findings Low-dose THC groups: Participants aged 18-35 were assigned to placebo, 5 mg THC, or 10 mg THC groups, with 12 people …

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Psilocybin AUD Trial Found Exploratory TLE4 and RASGRP4 Methylation Signals

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Psilocybin AUD Trial Found Exploratory TLE4 and RASGRP4 Methylation Signals

TL;DR: A 2026 exploratory study in Translational Psychiatry found blood DNA methylation changes after 25 mg psilocybin in detoxified alcohol use disorder patients, including findings near TLE4 and RASGRP4, but the small trial did not establish a definitive AUD biomarker. Key Findings 37 AUD patients: The methylation analysis used a randomized, double-blind psilocybin trial completed …

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Neonatal Gyri Showed Stronger Brain Connectivity Than Sulci

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Neonatal Gyri Showed Stronger Brain Connectivity Than Sulci

TL;DR: A 2026 study in Human Brain Mapping found that full-term neonates already showed stronger structural and functional connectivity between cortical gyri than between sulci, with brain structure-function coupling shifting toward decoupling around 41 weeks postmenstrual age. Key Findings Neonatal imaging sample: Researchers analyzed full-term neonates from the developing Human Connectome Project scanned between 38.14 …

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