EXPLORE THE SCIENCE
TL;DR: A 2026 mouse study in Proceedings of the National Academy of Sciences found that deleting or inhibiting PTP1B improved memory behavior, reduced amyloid-beta burden, and pushed microglia toward an amyloid-clearing state. Key Findings Memory behavior impr…
Read article
TL;DR: A 2026 study in Cell Chemical Biology found that alzheimer’s inflammation may be driven by a specific chemical switch: S-nitrosylation of STING at cysteine 148, which pushed innate immune signaling toward synaptic damage. Key Findings STING carried the…
Read article
TL;DR: A 2026 study in Neurology Open Access found that in 793 dementia-free adults, higher vitamin D levels around age 39 were associated with less tau readout on PET brain imaging about 16 years later, while amyloid beta did not show the same relationship. K…
Read article
TL;DR: A 2026 study in Nature Communications found that self-administered finger-prick blood tests for phosphorylated tau 217 (p-tau217), an Alzheimer’s tau marker, and glial fibrillary acidic protein (GFAP), an astrocyte-injury marker, correlated with cogniti…
Read article
TL;DR: A 2026 article-in-press study in Alzheimer’s Research & Therapy found that olfactory-region MRI radiomics, a method that turns brain scans into quantitative texture and shape features, linked blood pTau217, a tau-related Alzheimer’s disease biomarker, w…
Read article
TL;DR: A 2026 medRxiv preprint found that plasma p-tau217 AI models still separated amyloid-positive from amyloid-negative people across ADNI and A4, but calibration drift made the same probabilities less dependable for clinical decisions. Key Findings Calibra…
Read article
TL;DR: A 2022 study in Nature Communications used non-contrast 3D T2-FLAIR MRI, a scan that suppresses ordinary cerebrospinal-fluid brightness, to map possible brain-border drainage routes toward cervical lymph nodes, but FLAIR brightness alone does not prove…
Read article
TL;DR: A 2026 systematic review and meta-analysis in Molecular Neurobiology found that plasma phosphorylated tau 217 (p-tau217), a blood marker of Alzheimer-linked tau pathology, identified biomarker-defined Alzheimer’s disease with pooled sensitivity of 85.4%…
Read article
TL;DR: A 2026 medRxiv preprint tested SimulAD, an Alzheimer’s disease progression simulator, and reported that it reproduced mean amyloid-clearance results within 5% error across six major phase III anti-amyloid trials while also separating positive trials fro…
Read article
TL;DR: A 2026 study in Nature Neuroscience from Baylor College of Medicine showed that boosting Sox9, a transcription factor that regulates aging astrocytes, improved astrocytes’ ability to clear amyloid plaques in Alzheimer’s mouse models and preserved cognit…
Read article