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TL;DR: A 2026 study in npj Mental Health Research found that a 308-person multimodal MRI study found treatment-resistant depression carried a distinct structure-function decoupling pattern, and machine-learning models separated TRD from non-resistant depressio…
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Elevated methylmalonic acid (MMA) levels are associated with depressive symptoms and increased mortality risk, but depressive symptoms do not mediate the relationship between MMA and mortality. Highlights: Each standard deviation increase in MMA is associated…
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New research reveals that increased inflammation, indicated by higher levels of a protein called VCAM-1, is associated with decreased gray matter and altered brain connectivity in patients with major depressive disorder (MDD). These brain changes also correlat…
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A new case-control study reveals an association between obesity, depression, and decreased levels of the protein neuregulin-1 (NRG-1). The research suggests NRG-1 may serve as a biomarker linking depression and obesity. Key facts: Depressive symptoms were more…
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Suicide is a major public health problem, with over 700,000 people dying by suicide every year globally. Identifying factors that may indicate risk for suicidal thoughts and behaviors is an important area of research, as this could aid prevention and intervent…
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