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TL;DR: In brain scans of 149 adults, people whose migraine had turned into near-daily headaches from overusing painkillers had larger fluid-filled spaces around small brain vessels and a smaller hippocampus than people without migraine. The scans were taken on…
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TL;DR: Across four small studies, adults with vestibular migraine, a type that causes dizzy spells, scored noticeably lower on thinking tests than healthy people, even between attacks. The review was small and could not rule out anxiety, poor sleep or medicine…
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TL;DR: A 2026 review in Journal of Pain Research argued that G protein-coupled receptor 30 (GPR30/GPER), a membrane estrogen receptor, could help connect estrogen fluctuations with migraine biology. Key Findings Female-predominant migraine: The review notes a…
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Fluorinated Psilocin: The Sub-Hallucinogenic Breakthrough TL;DR: Chemists designed a new psilocin derivative with fluorine modifications that induces sub-hallucinogenic effects in mice, sidestepping the acute psychological effects of classic psychedelics while…
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Vestibular migraine is a disabling health condition characterized by severe, recurrent attacks of vertigo. A Cochrane review assessed the benefits and potential harms of medications used to try to prevent these attacks. Key Facts: Only 3 small studies, with 20…
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Cold stimulus headache, commonly known as “brain freeze”, is a curious and understudied phenomenon that many of us have experienced when eating or drinking something cold too quickly. Though brief and benign, these headaches provide insight into how the brain…
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A new network meta-analysis published in Frontiers in Pharmacology provides important insights into the relative efficacy and safety of monoclonal antibodies targeting calcitonin gene-related peptide (CGRP) for migraine prevention. This comprehensive analysis…
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Headaches are an extremely prevalent health issue, but medications can have side effects or lose effectiveness over time. Primary headaches, which have no identified underlying cause, include migraine, tension-type headache, and cluster headache. These cause s…
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