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TL;DR: A 2026 Nature Communications study used long-read single-cell RNA sequencing to map full-length isoforms in glioblastoma and found tumor-specific transcripts that short-read methods often miss. Key Findings 27 GBM samples: Researchers profiled histologi…
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TL;DR: A 2026 systematic review and meta-analysis in Neurological Sciences found that ketogenic diet (KD), a very-low-carbohydrate diet designed to raise ketone fuel use, looked feasible and generally safe as an add-on strategy in glioblastoma (GBM), but the s…
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TL;DR: A 2026 in vitro study in Molecular and Clinical Oncology found that amitriptyline reduced C6 glioma cell viability and PD-L1 checkpoint expression, but the same drug weakened the cell-killing effect of radiation when combined with temozolomide. Key Find…
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Nanoparticle-enhanced radiotherapy (NERT) is a promising approach to improving brain tumor treatment by enhancing radiotherapy efficacy through targeted delivery and radiosensitization while overcoming challenges posed by the blood-brain barrier. Highlights: M…
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Repurposing antipsychotics and antidepressants with favorable safety profiles and blood-brain barrier permeability shows promise for glioblastoma (GBM) treatment, primarily through disrupting lysosomal function and inducing cell death. Highlights: Mechanism of…
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Brain tumors can take a major toll on mental health. New research provides important insights into the psychiatric symptoms that often accompany these devastating diseases. Key Facts: Around 27% of brain tumor patients experience psychiatric symptoms like depr…
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