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TL;DR: A 2026 systematic review posted on medRxiv found that transcranial direct current stimulation (tDCS), a weak noninvasive brain-stimulation method, added to cognitive training produced a small short-term cognitive benefit across 27 trials, but the effect…
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TL;DR: A 2026 preprint in medRxiv reported that REDDI, an interpretable AI pipeline using resting-state magnetoencephalography (MEG), classified four neurodegenerative diseases with mean balanced accuracy of 0.81. Key Findings The dataset covered four disease…
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TL;DR: A 2026 Molecular Psychiatry study tested Regional Vulnerability Index for Alzheimer’s disease (RVI-AD), a structural-MRI score of how closely a person’s brain pattern resembles amyloid-positive Alzheimer’s disease, and found that higher RVI-AD predicted…
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TL;DR: A 2026 medRxiv preprint found that older adults with Montreal Cognitive Assessment (MoCA)-defined mild cognitive impairment had less coordinated pulse-wave responses during a cognitive challenge than cognitively intact older adults. Key Findings Communi…
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TL;DR: A 2026 machine-learning study found that the final SNP-NF model in PLOS One reported mAUC 0.965, recall 0.929, and precision 0.929, while the study reported gains of about 3% in mAUC, 1% in precision, and 0.7% in recall versus their previous neural-proc…
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TL;DR: A 2026 systematic review in The Cochrane Database of Systematic Reviews pooled 17 trials of anti-amyloid monoclonal antibodies (N=20,342 people with mild cognitive impairment or mild Alzheimer’s dementia) and concluded that any effect on memory decline…
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Blood GFAP Started Mirroring the Brain Only After the BBB Leaked TL;DR: Blood biomarkers mostly failed to mirror the brain while the blood-brain barrier stayed intact; once the barrier leaked, glial fibrillary acidic protein (GFAP), an astrocyte injury protein…
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Blood Test Detects Alzheimer’s with 83% Accuracy TL;DR: A new blood test using three misfolded plasma proteins can identify Alzheimer’s disease with 83.44% accuracy, outperforming conventional biomarkers and offering a non-invasive screening tool years before…
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Extended intra-nasal insulin (INI) treatment in an insulin-resistant early Mild Cognitive Impairment (MCI) patient improved grey matter volume, reduced beta-amyloid levels, and enhanced cognitive and pragmatic capacities, suggesting potential to slow neurodege…
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