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Early Locus Coeruleus Axon Loss May Explain Smell Loss in Alzheimer’s TL;DR: Alzheimer’s-model mice lost noradrenergic locus coeruleus axons in the olfactory bulb before major plaque buildup, took 60% longer to find buried food, and improved when microglial ph…
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Spinal Cord MRI Could Change Early Multiple Sclerosis Follow-Up TL;DR: Routine MS monitoring focuses on the brain — but prior data suggest 12% of new spinal cord lesions appear with no simultaneous brain activity. The MSpine trial is now testing whether system…
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AVATAR Therapy Outlasted CBT for Auditory Hallucinations TL;DR: AVATAR therapy matched CBT on voice severity right after treatment, then pulled ahead at 3 months — with roughly half the sessions. A 26-trial meta-analysis, 2,273 patients. Key Findings No clear…
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Gut Microbiome Signal Appeared Before Parkinson’s Symptoms in GBA1 Carriers TL;DR: In people carrying a genetic risk factor for Parkinson’s but not yet symptomatic, about 25% of their gut microbiome signature already looked intermediate between healthy control…
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SuperAgers Reveal Brain Biology of Preserved Memory TL;DR: Octogenarians who recall words like 50-year-olds carry a distinct brain profile: preserved cortical volume, a cingulate cortex thicker than younger adults, larger entorhinal neurons, fewer inflammatory…
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Autism Severity Showed Up in a Shared ADHD Connectome TL;DR: In 166 verbal children diagnosed with either autism or ADHD without autism, stronger resting-state coupling between the left middle frontal gyrus and posterior cingulate cortex tracked clinician-rate…
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Digital Faces Looked More Believable When Their Eyes Matched the Emotion TL;DR: A virtual smile or glare looked most believable with direct eye contact, while sadness became more believable when the digital face looked downward. Key Findings Direct gaze booste…
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Low-Level Drinking Was Not Invisible to the Aging Cortex TL;DR: Even drinking within low-risk guidelines was linked to lower cortical blood flow and thinner cortex when lifetime exposure met advancing age. Key Findings All participants stayed under 60 drinks p…
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Lifetime Cognitive Enrichment Delayed Alzheimer’s Dementia TL;DR: In 1,939 Rush Memory and Aging Project participants, higher lifetime cognitive enrichment was linked to 38% lower Alzheimer’s dementia hazard and about 5 years later dementia onset. Key Findings…
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Ketamine Restored Reward Bias Across Species TL;DR: Ketamine restored reward-learning bias in both treatment-resistant depression and chronically stressed rats while leaving basic discrimination unchanged. Key Findings Reward bias increased: Ketamine significa…
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