Depression

Perinatal EEG Delta and Alpha Power Tracked Depression and Anxiety

July 16, 2026 by BrainASAP

TL;DR: Portable electroencephalography (EEG) recordings tracked perinatal anxiety most consistently in a preliminary medRxiv preprint, with delta power carrying the clearest longitudinal marker and alpha power appearing in visit-specific anxiety analyses. Key Findings First-trimester marker: Relative delta power before 16 gestational weeks was associated with third-trimester PHQ-9 depression and GAD-7 anxiety scores. Delta-anxiety link: Across …

Phobic Anxiety Predicted Depression Treatment Response in Self-Report Study

July 15, 2026 by BrainASAP

TL;DR: A 2026 longitudinal study in Journal of Korean Medical Science found that self-reported phobic anxiety on the Symptom Checklist-90-Revised helped predict 2-month depression treatment response even when baseline clinician-rated depression and anxiety scores were similar. Key Findings Mood-disorder cohort was followed: The cohort included 157 people with major depressive disorder or bipolar disorder who …

Depression Reduced Alpha-Beta Reward Signaling in Movement Disorder Patients

July 15, 2026 by BrainASAP

TL;DR: A 2026 study in eNeuro used intracranial electroencephalography (EEG), a recording method for brain electrical activity, during deep brain stimulation surgery and found that Parkinson’s disease and essential tremor patients with elevated depression symptoms had weaker corticostriatal alpha-beta reward signaling. Key Findings 30 DBS patients participated: The sample included 14 Parkinson’s disease patients and …

CBT Online Self-Help Group Reduced Depression Symptoms in RCT

July 15, 2026 by BrainASAP

TL;DR: A 2026 randomized trial in JMIR mHealth and uHealth found that a 7-session CBT-based online self-help group reduced depression symptoms, with the average Beck Depression Inventory-II score moving from the moderate range to the mild range after the program. Key Findings Depression scores decreased: The CBT-based online self-help group fell from a mean BDI-II …

Academic Stress Protocol Will Track Depression, Cortisol, Diet, and Sleep

July 15, 2026 by BrainASAP

TL;DR: A 2026 study protocol in PLOS One describes a planned longitudinal study that will track academic stress, depressive symptoms, diet, sleep-related wearable measures, salivary cortisol, and other health indicators across a university semester, but it does not yet report outcome results. Key Findings Study protocol only: The source describes the planned design and hypotheses; …

Post COVID-19 Condition Linked to Fatigue, Sleep, Mood, and Subjective Cognition

July 15, 2026 by BrainASAP

TL;DR: A 2026 cross-sectional study in PLOS One found that people with post COVID-19 condition reported worse quality of life, fatigue, sleep, psychological wellbeing, and subjective cognition than COVID-19 survivors without the condition, while many objective lung, metabolic, and cognitive tests did not differ. Key Findings 139-person Dutch cohort: The study included 87 people with …

Creatine Monohydrate Showed Mixed Depression Trial Results

July 14, 2026 by BrainASAP

TL;DR: A 2026 review in Brain Medicine found mixed randomized-trial evidence for creatine monohydrate as an add-on depression treatment: 2 of 5 trials showed symptom benefits, while 3 did not find a clear advantage. Key Findings Five randomized trials were reviewed: The review summarized 238 baseline participants across trials of creatine monohydrate for mood disorders. …

Thalamus SC-FC Coupling Was Lower in Adolescent Bipolar Depression

July 13, 2026 by BrainASAP

TL;DR: A 2026 study in the European Journal of Nuclear Medicine and Molecular Imaging reported that adolescent bipolar II depression showed lower thalamic structural-functional connectivity coupling and glucose metabolism than adolescent major depressive disorder in a small exploratory positron emission tomography/MRI (PET/MRI) sample. Key Findings 28 adolescents scanned: The study compared 14 adolescents with bipolar …

Celecoxib Add-On to Antidepressants Reduced Depression Scores: Evidence Very Uncertain

July 12, 2026 by BrainASAP

TL;DR: A 2026 systematic review and meta-analysis in Brain, Behavior, & Immunity – Health found that adding celecoxib to antidepressants was linked to lower depressive symptom scores in 7 small trials, but the efficacy evidence was rated very low certainty. Key Findings 7 randomized trials: The meta-analysis included 365 adults with major depressive disorder, with …

Depression Nanomedicine Needs More Than Blood-Brain Barrier Delivery

July 11, 2026 by BrainASAP

TL;DR: A 2026 review in International Journal of Nanomedicine argued that depression nanomedicine should move beyond blood-brain-barrier delivery alone and be judged by target engagement, neuroimmune-barrier-plasticity effects, safety, manufacturability, and patient stratification. Key Findings Mechanism-centered review: The paper organized depression nanomedicine around neuroinflammation, blood-brain-barrier dysfunction, oxidative stress, and impaired neuroplasticity. 3 strategy groups: The review …

+ Load more