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TL;DR: A 2026 study in Annals of General Psychiatry found that, among 457 adults with recurrent major depressive disorder in Pakistan, escitalopram was the most common single antidepressant and reported side effects varied sharply by drug class. Key Findings C…
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TL;DR: A 2026 preprint on medRxiv tested transcutaneous vagus nerve stimulation (tVNS), a noninvasive ear-based stimulation method, during a grip-strength reward task and found that people with severe depressive symptoms made more efficient effort choices unde…
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TL;DR: A 2026 study in Journal of Korean Medical Science found that resistance exercise was more consistently associated with lower depression and anxiety scores than aerobic exercise in Korean adults, but the cross-sectional design means the study cannot prov…
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TL;DR: A 2026 cross-sectional study in BMC Geriatrics found that 43.9% of 945 older adults in Nepal’s Sudurpaschim Province screened positive for geriatric depression, and depression was linked to lower quality-of-life scores across every WHOQoL-8 domain. Key…
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TL;DR: A 2026 retrospective database study in Archives of Orthopaedic and Trauma Surgery found that people with major upper-extremity amputations had higher one-year rates of new mental-health diagnoses, antidepressant starts, and psychotherapy use than matche…
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TL;DR: A 2026 randomized trial in Scientific Reports found that adding esketamine to sufentanil patient-controlled analgesia lowered short-term postoperative depression and anxiety scores in elderly colorectal cancer surgery patients, without improving pain sc…
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TL;DR: A 2026 study in Nature Communications used resting-state functional MRI (fMRI) to link major depressive disorder to more frequent but shorter visits to a salience-dominated brain state. Key Findings Resting-state fMRI compared depression with controls:…
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TL;DR: A 2026 study in BMC Psychiatry found that structural MRI of the cerebellum separated first-episode bipolar depression from unipolar depression with 76.3% exploratory model accuracy, mainly because several cerebellar gray-matter regions were smaller in b…
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TL;DR: A 2026 MRI preprint on medRxiv found that patients with catatonia were less likely to have a left paracingulate sulcus (PCS), a stable anterior cingulate cortex fold, than psychiatric patients without catatonia. Key Findings 523 MRI scans: Researchers c…
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TL;DR: A 2026 study in Journal of Medical Case Reports described a 71-year-old breast-cancer survivor whose Montreal Cognitive Assessment (MoCA), a cognitive screening test, increased from 16 to 20 and whose 15-item Geriatric Depression Scale (GDS-15), a depre…
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