TL;DR: A 2026 cross-sectional study in BMC Geriatrics found that 43.9% of 945 older adults in Nepal’s Sudurpaschim Province screened positive for geriatric depression, and depression was linked to lower quality-of-life scores across every WHOQoL-8 domain. Key Findings Large household sample: Researchers interviewed 945 adults aged 60 years and older in Hill and Tarai districts …
TL;DR: A 2026 retrospective database study in Archives of Orthopaedic and Trauma Surgery found that people with major upper-extremity amputations had higher one-year rates of new mental-health diagnoses, antidepressant starts, and psychotherapy use than matched patients with minor hand or digit amputations. Key Findings Matched database study: Researchers compared 1,226 major upper-extremity amputation patients with …
TL;DR: A 2026 randomized trial in Scientific Reports found that adding esketamine to sufentanil patient-controlled analgesia lowered short-term postoperative depression and anxiety scores in elderly colorectal cancer surgery patients, without improving pain scores or increasing adverse events. Key Findings Three randomized groups: 91 older colorectal cancer surgery patients completed follow-up after assignment to sufentanil alone, …
TL;DR: A 2026 study in Nature Communications used resting-state functional MRI (fMRI) to link major depressive disorder to more frequent but shorter visits to a salience-dominated brain state. Key Findings Resting-state fMRI compared depression with controls: the analysis included 38 adults with major depressive disorder and 38 healthy controls. Structural-connectivity modeling used a smaller subset: …
TL;DR: A 2026 study in BMC Psychiatry found that structural MRI of the cerebellum separated first-episode bipolar depression from unipolar depression with 76.3% exploratory model accuracy, mainly because several cerebellar gray-matter regions were smaller in bipolar depression. Key Findings MRI cohort included three groups: Researchers analyzed structural MRI from 42 bipolar depression patients, 48 unipolar …
TL;DR: A 2026 MRI preprint on medRxiv found that patients with catatonia were less likely to have a left paracingulate sulcus (PCS), a stable anterior cingulate cortex fold, than psychiatric patients without catatonia. Key Findings 523 MRI scans: Researchers compared 109 patients with catatonia, 323 psychiatric patients without catatonia, and 91 healthy controls. Left PCS …
TL;DR: A 2026 study in Journal of Medical Case Reports described a 71-year-old breast-cancer survivor whose Montreal Cognitive Assessment (MoCA), a cognitive screening test, increased from 16 to 20 and whose 15-item Geriatric Depression Scale (GDS-15), a depression-symptom questionnaire, decreased from 8 to 2 after 12 sessions of left DLPFC, a prefrontal executive-control region, transcranial …
TL;DR: A 2026 functional MRI (fMRI) study in Psychological Medicine found that schizophrenia, bipolar disorder, and major depressive disorder shared some thalamus connectivity disruption, but each diagnosis showed a different subcortical network pattern across the thalamus, striatum, hippocampus, and amygdala. Key Findings 800-person MRI cohort: Researchers analyzed resting-state fMRI from 200 people with schizophrenia, 200 …
TL;DR: A 2026 mouse study in Neurochemical Research found that 28 days of unpredictable chronic mild stress increased dopamine D1 receptor binding across the striatum and raised dopamine D2 receptor binding only in selected regions, regardless of fatty acid-binding protein 7 gene deletion. Key Findings Adult male mice were exposed to 28 days of unpredictable …
TL;DR: A 2026 medRxiv preprint found psychomotor retardation, meaning slowed movement, speech, and thinking during depression, was linked to higher later Parkinson’s diagnosis risk in 6,327 London mental-health records. Key Findings Psychomotor retardation was common: Among 6,327 people with depression at age 40 or older, 2,402 patients, or 38.0%, had psychomotor retardation documented in records. …
