Solitary Confinement Harms Mental Health & Wellbeing But Reforms Can Help

A new study found that a program to provide more social contact and activities for prisoners in solitary confinement led to improved mental health and behavior. The program was based on a “Resource Team” model developed in Norway. Key Facts: Solitary confinement involves isolating prisoners in cells for 22+ hours per day with limited social …

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CRISPR Nasal Delivery Reduces Anxiety in Mice by Editing 5-HT2A Receptors in the Brain

Researchers developed a new gene editing technique that reduces anxiety in mice. The technique uses CRISPR technology to edit a specific gene in the brain called HTR2A. Editing this gene leads to lower levels of anxiety behaviors in tests with mice. This research demonstrates the potential of using gene editing tools like CRISPR to precisely …

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Smoking & Mental Health Problems: Unraveling The Complex Relationship

Cigarette smoking and mental health problems often go hand-in-hand. But which one typically comes first? And how much does our genetic makeup contribute to this risky combo? New research examined these questions by analyzing long-term health data on over 300,000 people in the UK. Key Facts: Smoking initiation typically happened in adolescence, before the first …

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Predicting Long-COVID Brain Fog: Blood Biomarkers Offer Clues

A new study published in Nature Medicine has identified two biological profiles, based on routine blood tests during COVID-19 hospitalization, that can predict patients’ risk of developing post-COVID brain fog months later. Key Facts: The study analyzed data from over 1,800 COVID-19 patients hospitalized in the UK. It linked certain patterns of blood biomarkers during …

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Retinal Imaging Detects Parkinson’s Up to 7 Years Before Diagnosis

A new neurology study provides compelling evidence that retinal imaging can detect Parkinson’s disease years before diagnosis. Researchers found thinning of two inner retinal layers – the ganglion cell-inner plexiform layer (GCIPL) and inner nuclear layer (INL) – in people who went on to develop Parkinson’s disease up to 7 years later. These findings suggest …

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Deciphering Ketamine’s Role in Depression Treatment

Researchers are gaining exciting new insights into how the drug ketamine can rapidly treat symptoms of depression, including in people who don’t respond to other antidepressants. Key facts about ketamine for depression: Ketamine is an FDA-approved anesthetic that has been found to quickly improve mood in depressed patients, including those with treatment-resistant depression. It works …

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Modafinil vs. Citalopram for Major Depression: Equally Effective Treatment?

A new study published in the journal Mædica – a Journal of Clinical Medicine compared the antidepressant effects of modafinil versus citalopram for treating major depressive disorder (MDD). The medications were equally effective at reducing depressive symptoms over a 6-week treatment period. Key facts: 30 patients with MDD were treated with either modafinil or citalopram …

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Epigenetics & Depression Links: New Insights into Causes & Treatments

Major depressive disorder affects over 280 million people worldwide. While the causes are complex, new research is uncovering the role epigenetics plays in depression. Epigenetic changes can regulate how genes are expressed without altering the DNA sequence itself. These changes may explain why some people are more susceptible to depression and highlight new avenues for …

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SSRIs & Teen Brains: Unveiling the Role of DLPFC in Depression Recovery

A new brain imaging study provides insight into how antidepressants like selective serotonin reuptake inhibitors (SSRIs) may bring about symptom improvement in adolescents with major depressive disorder. The findings suggest that changes in a brain region involved in cognitive control may serve as markers of treatment response. Key Facts: Researchers used MRI scans to examine …

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A Lesser Known Risk of SSRIs: Lifelong Irreversible Sexual Dysfunction

A new study reveals that widely prescribed antidepressants may cause persistent erectile dysfunction in a small but significant number of male patients. Key Facts: The study found that serotonergic antidepressants like SSRIs and SNRIs triple the risk of erectile dysfunction (ED) compared to non-users. After stopping the antidepressants, 0.46% of patients (1 out of every …

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