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TL;DR: A 2026 systematic review and meta-analysis in Journal of Alzheimer’s Disease found that choroid plexus volume, an MRI-visible structure involved in cerebrospinal-fluid regulation and immune signaling, was larger in Alzheimer’s disease than in healthy co…
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TL;DR: A 2026 open-label study in Communications Medicine found that Bacillus Calmette-Guerin (BCG) immunotherapy changed cerebrospinal-fluid immune-cell responses and Alzheimer-related biomarkers in 23 older adults. Key Findings Small trial context: 2 related…
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TL;DR: A 2026 cross-sectional metabolomics study in Brain, Behavior, & Immunity – Health found that serum and cerebrospinal fluid (CSF) metabolite signatures differed in knee osteoarthritis and related to pain, fatigue, sleep, and pressure sensitivity, while C…
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TL;DR: A 2026 mouse study in Nature Neuroscience found that abdominal muscle contractions during locomotion drove directed brain motion and helped move interstitial fluid through brain tissue during wakefulness. Key Findings Brain motion was tightly coupled to…
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Ethanolamine Looked Like a Depression Biomarker and Treatment Target TL;DR: In a 380-person cerebrospinal fluid dataset, patients with active major depression had lower ethanolamine levels than controls, those levels rose after electroconvulsive therapy, and p…
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Researchers have found signs of ongoing inflammation in the brains of athletes still experiencing concussion symptoms months or years after their injury, according to a new study published in Journal of Neuroinflammation. The findings suggest the concussion tr…
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