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TL;DR: A 2026 study in eNeuro used intracranial electroencephalography (EEG), a recording method for brain electrical activity, during deep brain stimulation surgery and found that Parkinson’s disease and essential tremor patients with elevated depression symp…
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TL;DR: A 2026 review and activation-likelihood estimation study in European Journal of Pain found that the dorsolateral prefrontal cortex (dlPFC), a frontal control region, was repeatedly engaged in acute pain, chronic pain, and placebo analgesia, mainly acros…
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TL;DR: A 2026 medRxiv preprint found that one session of repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) reduced cigarette craving in adults with tobacco use disorder, and the people who responded had he…
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TL;DR: A 2026 randomized trial posted to medRxiv found that connectivity-guided accelerated intermittent theta-burst stimulation added to inpatient care improved treatment-resistant depression scores more than sham stimulation over 2 weeks. Key Findings 57 ran…
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TL;DR: A 2026 randomized controlled study in Pakistan Journal of Pharmaceutical Sciences found that adding 20 Hz repetitive transcranial magnetic stimulation (rTMS) to risperidone was linked with lower cognitive-factor and aggression scores after 4 weeks in sc…
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TL;DR: A 2026 study in Journal of Medical Case Reports described a 71-year-old breast-cancer survivor whose Montreal Cognitive Assessment (MoCA), a cognitive screening test, increased from 16 to 20 and whose 15-item Geriatric Depression Scale (GDS-15), a depre…
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DLPFC-sgACC Circuit Signal Predicted rTMS Remission TL;DR: Before starting rTMS, patients who later remitted from depression showed lower alpha-band connectivity flowing from the DLPFC to the subgenual cingulate — pointing toward a measurable EEG marker that c…
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Depression Genetics Points to Altered DLPFC Cell Types TL;DR: A Nature Genetics study mapped more than 200,000 cells from the dorsolateral prefrontal cortex and found depression-linked regulatory changes concentrated in deep-layer excitatory neurons and a micr…
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Repetitive transcranial magnetic stimulation (rTMS) on the left dorsolateral prefrontal cortex (dlPFC) improves decision-making and reduces cravings in individuals with methamphetamine use disorder (MUD). Highlights: Improved Decision-Making: rTMS treatment en…
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Personality disorders like borderline and avoidant involve differences in brain structure and function that relate to symptoms. New research sheds light on the neurobiology underlying these disorders. Key Facts: Borderline patients showed reduced medial prefro…
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