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TL;DR: A 2026 study in Psychological Medicine found that cognitive reserve in non-affective first-episode psychosis was higher with greater genetic predisposition to educational attainment and lower with earlier psychosis onset or family history of psychosis.…
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TL;DR: A 2026 review in Current Opinion in Psychiatry found that earlier clozapine use in schizophrenia, especially after early nonresponse or relapse, was linked to better relapse prevention and stronger response rates than repeated nonclozapine antipsychotic…
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TL;DR: A 2026 study in The British Journal of Psychiatry found that in first-episode psychosis, MRI deviations from age-matched brain norms at illness onset helped predict which patients would carry heavier symptom burdens and poorer functioning for years afte…
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C4A Broke Away From C1Q in First-Episode Psychosis TL;DR: In cerebrospinal fluid from people with first-episode psychosis, the usual positive relationship between C4A and C1Q disappeared, while C4A’s broader immune-network pattern shifted sharply in a way C4B…
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