TDP43 Failure Disrupts DNA Repair in ALS and FTD
TL;DR: TDP43, the protein that misfires in ALS and FTD, secretly controls DNA repair genes—and when it breaks, mutations pile up in neurons, potentially explaining both neurodegeneration and the cancer link in these diseases. A protein known for its role in neurodegenerative disease has a hidden job: keeping the cell’s DNA repair crew on task. …
