EXPLORE THE SCIENCE
TL;DR: A 2026 study in Molecular Psychiatry found that radiofrequency capsulotomy and inferior thalamic peduncle deep brain stimulation were associated with the largest symptom improvements among surgical strategies for refractory obsessive-compulsive disorder…
Read article
TL;DR: A 2026 trial in Journal of Psychopharmacology found that repeated supervised psilocybin sessions reduced Yale-Brown Obsessive Compulsive Scale (YBOCS) scores, a standard measure of obsession and compulsion severity, in 15 adults with OCD. Key Findings 7…
Read article
TL;DR: A 2026 preprint in medRxiv found that deep brain stimulation for severe obsessive-compulsive disorder was followed by lower globus pallidus externus alpha-band activity in clinically responsive patients, suggesting a possible brain readout of sustained…
Read article
TL;DR: A 2026 preprint in medRxiv used whole-genome sequencing in two families with many obsessive-compulsive disorder (OCD) cases and prioritized rare variants in NPY5R, DLGAP1, and MAPK8IP3, but the findings still need replication and functional testing. Key…
Read article
TL;DR: A 2026 systematic review and meta-analysis in Acta Neuropsychiatrica found no clear evidence that parenteral clomipramine is better than oral clomipramine for depression or obsessive-compulsive disorder, with low or very low certainty across the main ra…
Read article
TL;DR: A 2026 medRxiv preprint reported that ventral capsule deep brain stimulation (DBS), an implanted brain-stimulation treatment, reduced severe treatment-resistant obsessive-compulsive disorder (OCD) symptoms by 22 Yale-Brown Obsessive-Compulsive Scale (Y-…
Read article