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TL;DR: A 2026 study in Translational Psychiatry found that ketamine changed EEG-derived high-order brain interactions in late-life treatment-resistant depression, and a 24-hour increase in alpha-band redundancy tracked greater depression improvement by Day 7.…
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TL;DR: A 2026 study in The British Journal of Psychiatry found that 4 weeks of twice-weekly subcutaneous racemic ketamine helped a minority of people with treatment-resistant depression, but response fell from 30% at treatment end to 17% 4 weeks later. Key Fin…
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TL;DR: A 2026 randomized trial posted to medRxiv found that connectivity-guided accelerated intermittent theta-burst stimulation added to inpatient care improved treatment-resistant depression scores more than sham stimulation over 2 weeks. Key Findings 57 ran…
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TL;DR: A 2026 preprint in medRxiv found that treatment-resistant depression affected 34% of medication-exposed major-depression patients in Pakistan’s DIVERGE study, with social support and CYP2C19 metabolizer status standing out as locally important treatment…
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TL;DR: A 2026 study in Interactive Journal of Medical Research used structured hospital records plus natural language processing of clinical notes to profile major depressive disorder in Belgium, finding that 46% of 1,147 adults met a real-world treatment-resi…
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TL;DR: A 2026 retrospective case series study in European Journal of Psychotraumatology found that trauma flashbacks during esketamine nasal spray sessions were distressing but usually time-limited in 22 patients with treatment-resistant depression and PTSD; w…
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TL;DR: A 2026 mouse study in Cell traced ketamine’s rapid antidepressant-like effect to mu-opioid receptors on somatostatin-positive interneurons in the medial prefrontal cortex. Low-dose multi-GPCR targeting reproduced ketamine-like effects in mice, but the e…
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TL;DR: A 2026 preprint deep brain stimulation biomarker study in medRxiv found that home-recorded electrophysiology biomarkers tracked stable depression recovery during SCC DBS, while the biomarkers helped distinguish recovery from nonspecific symptom fluctuat…
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TL;DR: A 2026 study in npj Mental Health Research found that a 308-person multimodal MRI study found treatment-resistant depression carried a distinct structure-function decoupling pattern, and machine-learning models separated TRD from non-resistant depressio…
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Esketamine Lost the Cost-Effectiveness Race in Hong Kong TL;DR: A 5-year Hong Kong model found esketamine plus an antidepressant bought only a small quality-adjusted survival gain at US$29,061 per patient, leaving it behind cheaper third-line options like comb…
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