treatment-resistant depression Archives

Ketamine’s Antidepressant Pathway Reverse-Engineered: Low-Dose Three-Drug Combination Reproduced Effect in Mice

May 25, 2026May 25, 2026 by BrainASAP

TL;DR: A 2026 mouse study in Cell traced ketamine’s rapid antidepressant-like effect to mu-opioid receptors on somatostatin-positive interneurons in the medial prefrontal cortex. Low-dose multi-GPCR targeting reproduced ketamine-like effects in mice, but the exact three compound names were not listed in the public source material verified here. Key Findings Cell target: ketamine’s rapid mouse effect …

Home DBS Recordings Tracked Depression Recovery Biomarkers

May 24, 2026 by BrainASAP

TL;DR: A 2026 preprint deep brain stimulation biomarker study in medRxiv found that home-recorded electrophysiology biomarkers tracked stable depression recovery during SCC DBS, while the biomarkers helped distinguish recovery from nonspecific symptom fluctuations and external distress. Key Findings Study type: a home-recording study using bidirectional deep brain stimulation devices to monitor electrophysiology during depression recovery. …

TRD Brain Networks Decoupled Structure From Function

May 22, 2026 by BrainASAP

TL;DR: A 2026 study in npj Mental Health Research found that a 308-person multimodal MRI study found treatment-resistant depression carried a distinct structure-function decoupling pattern, and machine-learning models separated TRD from non-resistant depression with AUCs up to 0.95. Key Findings 72 TRD patients analyzed: The final sample included 72 patients with treatment-resistant depression, 152 with …

Esketamine Was Not “Cost-Effective” for Treatment-Resistant Depression in Hong Kong

May 15, 2026May 6, 2026 by BrainASAP

Esketamine Lost the Cost-Effectiveness Race in Hong Kong TL;DR: A 5-year Hong Kong model found esketamine plus an antidepressant bought only a small quality-adjusted survival gain at US$29,061 per patient, leaving it behind cheaper third-line options like combination therapy. Key Findings Seven third-line strategies modeled: A Markov cohort model followed adults with treatment-resistant depression in …

Ketamine Effective for Treatment-Resistant Depression: No Added Benefit from Music

May 15, 2026May 6, 2026 by BrainASAP

Ketamine Improved Severe Depression Without Music Support

TL;DR: A 2026 randomized trial in The British Journal of Psychiatry found 6 ketamine infusions improved severe treatment-resistant depression, but curated music added no measurable benefit; higher mystical-experience scores still predicted the next session’s depression outcome. Key Findings MADRS fell 11.8 points by week 4: Scores dropped from 31.5 to 19.7 (d = 1.2, p …

Ketamine Restored Reward Bias in Depression and Stressed Rats

May 15, 2026May 3, 2026 by BrainASAP

Ketamine Restored Reward Bias Across Species TL;DR: Ketamine restored reward-learning bias in both treatment-resistant depression and chronically stressed rats while leaving basic discrimination unchanged. Key Findings Reward bias increased: Ketamine significantly increased response bias toward the more frequently rewarded stimulus in both species. Healthy-control levels returned: The reward-bias effect reached levels comparable with healthy controls …