Artificial Intelligence (AI)

FP-CIT SPECT Ratios Improved Parkinsonism Classification

July 11, 2026 by BrainASAP

TL;DR: A 2026 study in European Journal of Nuclear Medicine and Molecular Imaging found that semiquantitative [123I]FP-CIT SPECT metrics, especially caudate-to-putamen and sensorimotor-to-limbic ratios, helped distinguish Parkinson’s disease from atypical parkinsonian syndromes, while a random forest classifier remained more useful as decision support than as a standalone diagnosis. Key Findings 706-patient cohort: The study included …

AI Chatbots Did Not Significantly Reduce Depression Symptoms in Meta-Analysis

July 10, 2026 by BrainASAP

TL;DR: A 2026 meta-analysis in Journal of Medical Internet Research did not find a statistically significant reduction in Patient Health Questionnaire-9 (PHQ-9) depression scores with AI-driven chatbots, but emotionally responsive, structured, and frequent interactions were more consistently associated with user adherence. Key Findings 11 randomized trials: The review included 11 RCTs with 2220 participants for …

GPT-4 Turbo Debate Impersonation Increased Authenticity Ratings

July 8, 2026 by BrainASAP

TL;DR: A 2026 study in PLOS One found that UK survey participants rated LLM-generated impersonated debate responses as more authentic, coherent, and relevant than real televised-debate answers, even though many generated answers differed from what the real speakers said. Key Findings 948 UK participants: The survey used a representative cross-section of British society to rate …

Focused Ultrasound and rTMS Had Similar Stroke Motor Endpoints

July 4, 2026 by BrainASAP

TL;DR: A 2026 secondary analysis in PLOS One found that low-intensity focused ultrasound and repetitive transcranial magnetic stimulation (rTMS) had similar short-term post-stroke motor endpoint scores, while change-from-baseline Fugl-Meyer gains were larger with focused ultrasound. Key Findings 50-person comparison: The analysis compared 25 subacute stroke patients assigned to LIFU with 25 assigned to rTMS. 10 …

rTMS Plus Risperidone Improved Schizophrenia Cognitive and Aggression Scores

July 4, 2026 by BrainASAP

TL;DR: A 2026 randomized controlled study in Pakistan Journal of Pharmaceutical Sciences found that adding 20 Hz repetitive transcranial magnetic stimulation (rTMS) to risperidone was linked with lower cognitive-factor and aggression scores after 4 weeks in schizophrenia patients. Key Findings Schizophrenia trial sample: The single-center trial randomized 80 patients, with 40 assigned to risperidone alone …

MR-AIV Brain Fluid Transport AI Stayed Robust Across Modeling Tests

July 3, 2026 by BrainASAP

TL;DR: A 2026 preprint in bioRxiv found that Magnetic Resonance Artificial Intelligence Velocimetry (MR-AIV), a physics-informed AI method for estimating brain fluid transport, produced stable velocity and permeability maps across several modeling stress tests. Key Findings Brain-fluid target: MR-AIV estimates three-dimensional velocity, pressure, and permeability fields from dynamic contrast-enhanced MRI. 10-region initialization: A universal, anatomically …

Trichostatin A Alzheimer’s Screen Flagged 8 Core Genes but Weak Direct Binding

July 1, 2026 by BrainASAP

TL;DR: A 2026 computational study in PLOS One used GEO Alzheimer’s datasets, 130 machine-learning models, and molecular simulations to identify eight candidate genes that may sit in a trichostatin A-related Alzheimer’s disease network. Key Findings 949 predicted TSA targets: The analysis started with predicted human protein targets for trichostatin A, a histone deacetylase inhibitor. Five …

AI-Guided Variable Levodopa Feasible in 5 Parkinson’s Patients

June 30, 2026 by BrainASAP

TL;DR: A 2026 open-label feasibility trial in IBRO Neuroscience Reports tested an AI-guided variable levodopa schedule in 5 people with Parkinson’s disease and found 4 patients improved on UPDRS, but the study was far too small and uncontrolled to prove efficacy. Key Findings Feasibility sample: The single-center trial enrolled 5 people with Parkinson’s disease after …

EHR NLP Study Found 46% Treatment-Resistant Depression in Belgian MDD Cohort

July 9, 2026June 28, 2026 by BrainASAP

TL;DR: A 2026 study in Interactive Journal of Medical Research used structured hospital records plus natural language processing of clinical notes to profile major depressive disorder in Belgium, finding that 46% of 1,147 adults met a real-world treatment-resistant depression definition. Key Findings Belgian EHR cohort: The retrospective study drew from 1,147 adults with major depressive …

iSupport-Malaysia Dementia Caregiver Platform Scored Above Usability Benchmark

June 28, 2026 by BrainASAP

TL;DR: A 2026 preprint posted on medRxiv found that iSupport-Malaysia, a culturally adapted multimedia dementia-caregiver platform, scored above the usual usability benchmark and was viewed as culturally appropriate by caregivers and healthcare professionals. Key Findings Four-phase adaptation: The WHO iSupport dementia program was translated into Bahasa Malaysia, culturally adapted, and rebuilt as multimedia e-learning. 23 …

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