TL;DR: A 2026 study in Psychopharmacology found that after 14 days of unpredictable chronic stress, a single 1-hour ayahuasca exposure restored sociability, reduced anxiety-like behavior, normalized cortisol, and rescued whole-brain BDNF in adult zebrafish within 24 hours. Key Findings 396 fish across 6 groups: Adult zebrafish were split into stressed and non-stressed groups, then exposed …
TL;DR: A 2025 randomized trial in Scandinavian Journal of Primary Health Care found that a self-help book based on cognitive behavioral therapy for insomnia (CBT-I), a structured non-drug insomnia treatment, reduced daily hypnotic sleep-medication use and anxiety screening rates more than a brief sleep-hygiene handout among Norwegian general-practice patients prescribed zopiclone or zolpidem. Key Findings …
TL;DR: A 2026 medRxiv preprint reported that ventral capsule deep brain stimulation (DBS), an implanted brain-stimulation treatment, reduced severe treatment-resistant obsessive-compulsive disorder (OCD) symptoms by 22 Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) points on average in 10 participants. Key Findings 10 severe OCD patients: Researchers implanted bilateral ventral internal capsule DBS leads in participants with intractable obsessive-compulsive …
TL;DR: A 2026 mouse preprint in bioRxiv found that psilocybin reduced firing in somatostatin (SST) interneurons, inhibitory cortical cells that gate dendritic input, while increasing parvalbumin (PV) interneuron firing in the medial frontal cortex. Key Findings SST firing decreased: Opto-tagged SST interneurons fell from 5.5 to 3.7 Hz after psilocybin, while saline did not produce …
TL;DR: A 2026 systematic review and exploratory network meta-analysis of 5 randomized trials in Neurological Sciences found dose-specific ON-medication motor improvements, measured while usual Parkinson’s drugs were active, for some GLP-1 receptor agonists, glucose-related metabolic hormone drugs, in Parkinson’s disease, but broader motor, non-motor, and quality-of-life evidence remained limited. Key Findings 5 randomized trials: The …
TL;DR: A 2026 systematic review and meta-analysis in Neuropsychopharmacology found that dopamine D2-like receptor activation suppressed glucose-stimulated insulin secretion (GSIS), insulin release after high glucose, in animal pancreatic cells, suggesting one peripheral route by which antipsychotic dopamine blockade can disturb glucose control beyond weight gain. Key Findings 39 eligible studies: Researchers screened 12,457 citations and …
TL;DR: A 2026 mouse and rat study in Molecular Psychiatry reported that 25C-NBF, a selective serotonin 2A receptor agonist from the 2C-X phenethylamine series, produced rapid antidepressant-like effects, increased dendritic spines and Bdnf expression in the prefrontal cortex, and showed no rewarding or reinforcing properties at the tested doses. Key Findings Despair behavior fell after …
TL;DR: A 2026 cross-sectional study in PLOS One found that euthymic bipolar disorder patients with early systematic antidepressant treatment had higher negative affect and higher attentional, non-planning, and total impulsivity scores than matched patients without that early antidepressant history. Key Findings 124 bipolar patients studied: Researchers compared 62 patients with early systematic antidepressant treatment and …
TL;DR: A 2026 mouse study in Psychopharmacology found that repeated dexamethasone, a synthetic glucocorticoid steroid, disrupted light-phase sleep and increased orexin-neuron activity, a wake-promoting hypothalamic signal, during sleep-to-wake transitions. Key Findings 5-day steroid model: Male C57BL/6J mice received dexamethasone at 30 mg/kg for 5 days before 24-hour sleep recording. Light-phase sleep was disrupted: Dexamethasone increased …
TL;DR: A 2026 systematic review in Journal of Clinical Sleep Medicine found that cognitive behavioral therapy for insomnia (CBT-I), a structured behavioral sleep treatment, plus sleep medication improved chronic insomnia more than medication alone, but adding medication to CBT-I did not improve the critical insomnia outcomes. Key Findings 15 analyzable articles: Researchers screened 1,179 articles, …
