TL;DR: A 2026 study in Neuropsychopharmacology found that 30 mg 2C-B produced acute subjective effects in healthy adults that were similar in overall intensity to 125 mg MDMA, shorter and less distressing than 25 mg psilocybin, and less cardiovascularly stimulating than MDMA. Key Findings Crossover comparison: The double-blind study tested 10, 20, and 30 mg …
TL;DR: A 2026 retrospective analysis posted to medRxiv linked diclofenac and naproxen use in the NACC cohort to lower dementia and Alzheimer disease prevalence, while diclofenac use was also associated with slower Montreal Cognitive Assessment (MoCA) cognitive-screening decline. Key Findings NACC cohort: The analysis used 47,165 National Alzheimer’s Coordinating Center participants with data collected from …
TL;DR: A 2026 protocol posted to medRxiv describes a nationwide Japan survey designed to measure how dementia specialists handle anti-amyloid antibody therapy, biomarker testing, MRI safety monitoring, service capacity, and patient-choice tradeoffs. Key Findings Nationwide specialist survey: The protocol targets board-certified dementia specialists in Japan, especially physicians trained for anti-amyloid antibody therapy. June 2026 data …
TL;DR: A 2026 study in Oncoscience reported that nitrosylcobalamin, a nitric-oxide-releasing vitamin B12 analog, crossed the blood-brain barrier in glioblastoma-bearing rats and accumulated in tumor tissue. Key Findings NO-Cbl defined: Nitrosylcobalamin is a cobalamin-based nitric oxide donor designed to exploit the transcobalamin II receptor CD320. 17.6 µM ID50: Central nervous system tumor cell lines in …
TL;DR: A 2026 mouse study in Alcohol: Clinical and Experimental Research found that chronic intermittent ethanol plus repeated forced-swim stress left mice drinking more alcohol months later and impaired reversal learning in midlife, alongside locus coeruleus signs of oxidative stress and weaker adrenergic autoregulation. Key Findings Persistent effects reached midlife: The experiment followed 55 C57BL/6J …
TL;DR: A 2026 methodology paper in European Archives of Psychiatry and Clinical Neuroscience describes EMBER-MDD, a research-only multi-omic study designed to find treatment-resistance and esketamine-response biomarkers in about 420 adults with major depressive disorder. Key Findings About 420 adults: EMBER-MDD will analyze biomaterials from approximately 420 adults with major depressive disorder. 210 versus 210 design: …
TL;DR: A 2026 review in Journal of Pain Research argues that postoperative pain care is moving away from opioid-centered prescribing toward multimodal, opioid-sparing protocols, with the strongest practical signal around NSAIDs paired with dexamethasone or regional anesthesia and the largest unresolved gap after hospital discharge. Key Findings More than 80% affected: The review describes postoperative …
TL;DR: A 2026 review in International Journal of Molecular Medicine summarized how tanshinone IIA, a compound from Salvia miltiorrhiza, may protect cardiovascular and cerebrovascular tissue through anti-inflammatory, antioxidant, anti-apoptotic, and nanodelivery-linked mechanisms. Key Findings Four mechanism families: The review grouped tanshinone IIA activity around inflammation, oxidative stress, apoptosis/fibrosis, and pathway regulation. Three named pathways: TLR4/NF-kB, …
TL;DR: A 2026 study in Molecular Psychiatry found that radiofrequency capsulotomy and inferior thalamic peduncle deep brain stimulation were associated with the largest symptom improvements among surgical strategies for refractory obsessive-compulsive disorder. Key Findings 75 studies: The network meta-analysis included 75 studies, 1,259 patients, and 20 surgical strategies for refractory obsessive-compulsive disorder. Y-BOCS was primary: …
TL;DR: A 2026 study in Implementation Science Communications found that high-performing HEALing Communities Study coalitions used representative membership, shared goals, data support, and communications campaigns to strengthen opioid-use-disorder service implementation. Key Findings 8 communities studied: Researchers selected the top-performing urban and rural waitlist-control communities from each of four HEALing Communities Study sites. 41 interviews analyzed: …
