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TL;DR: A 2026 medRxiv review found that mental-health AI agents are moving quickly toward large-language-model chatbots, but most systems still rely on text self-report, narrow depression/anxiety/suicide use cases, and offline tests rather than prospective cli…
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TL;DR: A 2026 study in Biological Psychiatry: Global Open Science found that trauma-exposed adolescents, especially those with higher posttraumatic stress symptoms, showed disrupted parent-cued fear extinction across skin-conductance, behavioral-learning, and…
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TL;DR: A 2026 study in Aging Cell found that fasting and caloric restriction activated ADIOL, a steroid hormone, through an NHR-91-kynurenic acid pathway that improved several healthspan measures in worms without extending lifespan. Key Findings ADIOL was the…
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TL;DR: A 2026 medRxiv preprint from the ENIGMA Addiction Working Group used structural MRI from 2,782 people with substance use disorder (SUD) and 1,951 controls and reported that addiction-related brain differences followed cortical network hubs and neurotran…
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TL;DR: A 2026 study in Psychological Medicine found that people with schizophrenia spectrum disorders and higher avolition or moderate-to-high delusion severity appeared to improve more after virtual reality cognitive behavioral therapy for psychosis (VR-CBTp)…
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TL;DR: A 2026 rat and cell study in Journal of Materials Science: Materials in Medicine reported that an engineered VIN nanosystem shifted microglia toward an anti-inflammatory state and reduced ischemic-stroke infarct measures in MCAO rats. Key Findings CXCR4…
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TL;DR: A 2026 preprint in medRxiv found that under-mattress sleep sensors associated lower nighttime respiratory rate and more unstable nighttime movement with higher odds of next-day agitation in dementia, while the same features did not predict how severe ag…
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TL;DR: A 2026 preprint on medRxiv tested transcutaneous vagus nerve stimulation (tVNS), a noninvasive ear-based stimulation method, during a grip-strength reward task and found that people with severe depressive symptoms made more efficient effort choices unde…
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TL;DR: A 2026 machine-learning study in PLOS One used student mental-health survey features to test an interpretable FT-Transformer plus LSTM model, which reached 95% accuracy for low, medium, and high risk prediction in a public dataset. Key Findings 95% accu…
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TL;DR: A 2026 review in Neuroscience & Biobehavioral Reviews found that chronic primary pain studies most consistently linked higher pain sensitivity with lower mean arterial pressure, higher cortisol, higher heart rate during recovery, and lower parasympathet…
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