Medical

Half of 292 Adult ADHD Randomized Trials Skipped a General Psychopathology Assessment, Scoping Review Found

by
Half of 292 Adult ADHD Randomized Trials Skipped a General Psychopathology Assessment, Scoping Review Found

TL;DR: A 2025 scoping review in European Psychiatry screened 292 randomized trials of adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) and reported that 49.7% did not assess general psychopathology and only 35% had the ADHD diagnosis allocated by a psychiatrist or psychologist. Key Findings Half of the trials skipped a general psychopathology check: 49.7% of the …

Read more

25C-NBF, a Selective 5-HT2A Phenethylamine, Reduced Despair and Restored Sucrose Preference in Male Mice

by
25C-NBF, a Selective 5-HT2A Phenethylamine, Reduced Despair and Restored Sucrose Preference in Male Mice

TL;DR: A 2026 mouse and rat study in Molecular Psychiatry reported that 25C-NBF, a selective serotonin 2A receptor agonist from the 2C-X phenethylamine series, produced rapid antidepressant-like effects, increased dendritic spines and Bdnf expression in the prefrontal cortex, and showed no rewarding or reinforcing properties at the tested doses. Key Findings Despair behavior fell after …

Read more

CBT-I Plus Medication Improved Chronic Insomnia More Than Medication Alone

by
CBT-I Plus Medication Improved Chronic Insomnia More Than Medication Alone

TL;DR: A 2026 systematic review in Journal of Clinical Sleep Medicine found that cognitive behavioral therapy for insomnia (CBT-I), a structured behavioral sleep treatment, plus sleep medication improved chronic insomnia more than medication alone, but adding medication to CBT-I did not improve the critical insomnia outcomes. Key Findings 15 analyzable articles: Researchers screened 1,179 articles, …

Read more

BIOMEDE Trial Found No Survival Gain From Targeted Drugs in DIPG

by
BIOMEDE Trial Found No Survival Gain From Targeted Drugs in DIPG

TL;DR: A 2026 randomized phase 2 trial in Nature Medicine found that three targeted drugs added to radiotherapy did not improve overall survival for children with diffuse intrinsic pontine glioma (DIPG), a lethal brainstem tumor, although everolimus caused fewer treatment-stopping side effects. Key Findings 233 randomized patients: BIOMEDE assigned 36 children to erlotinib, 102 to …

Read more

Olfactory MRI Radiomics Linked pTau217 to Alzheimer’s Cognition

by
Olfactory MRI Radiomics Linked pTau217 to Alzheimer's Cognition

TL;DR: A 2026 article-in-press study in Alzheimer’s Research & Therapy found that olfactory-region MRI radiomics, a method that turns brain scans into quantitative texture and shape features, linked blood pTau217, a tau-related Alzheimer’s disease biomarker, with cognitive impairment across three cohorts. Key Findings Three Alzheimer’s cohorts were matched: Researchers matched 122 Alzheimer’s disease (AD) patients …

Read more

Alzheimer’s AI Model Improved Disease Progression Prediction

by
Alzheimer's AI Model Improved Disease Progression Prediction

TL;DR: A 2026 machine-learning study found that the final SNP-NF model in PLOS One reported mAUC 0.965, recall 0.929, and precision 0.929, while the study reported gains of about 3% in mAUC, 1% in precision, and 0.7% in recall versus their previous neural-process model. Key Findings SNP-NF performance was high: The final model reported mAUC …

Read more

Natural Daylight During Office Hours Improved Glucose Time-in-Range and Shifted Substrate Metabolism in Type 2 Diabetes

by
Natural Daylight During Office Hours Improved Glucose Time-in-Range and Shifted Substrate Metabolism in Type 2 Diabetes

TL;DR: A 2026 randomized crossover trial in Cell Metabolism compared natural daylight against standard artificial office lighting in 13 older adults with well-controlled type 2 diabetes and found that natural-daylight days produced more time in a healthy blood-glucose range (about 51% vs 43%), smaller glucose swings, and a metabolic shift toward burning more fat and …

Read more

Three or More Live Births Was the Only Reproductive Factor Linked to Lower Stroke Risk in Framingham Women

by
Three or More Live Births Was the Only Reproductive Factor Linked to Lower Stroke Risk in Framingham Women

TL;DR: A 2026 study in the Journal of the American Heart Association followed 1,882 stroke-free women from the Framingham Heart Study for a median of 18 years and found that having three or more live births was associated with a reduced risk of clinical stroke and lower MRI markers of vascular brain injury — the …

Read more

Acute and Post-Acute Settings Initiated Most Cognition-Altering Prescriptions in Older Adults With Dementia

by
Acute and Post-Acute Settings Initiated Most Cognition-Altering Prescriptions in Older Adults With Dementia

TL;DR: A 2026 study in JAMA Network Open analyzed Medicare claims for adults 66+ from 2008 to 2021 and found that cognition-altering medications — antipsychotics, benzodiazepines, hypnotics, anticholinergics — were disproportionately initiated in emergency rooms, hospitals, and skilled nursing facilities rather than doctors’ offices, especially in dementia patients (43% of antipsychotic starts vs 22% of …

Read more

Cochrane Review of 17 Trials Found Anti-Amyloid Antibodies Made No Clinically Meaningful Difference in Early Alzheimer’s

by
Cochrane Review of 17 Trials Found Anti-Amyloid Antibodies Made No Clinically Meaningful Difference in Early Alzheimer's

TL;DR: A 2026 systematic review in The Cochrane Database of Systematic Reviews pooled 17 trials of anti-amyloid monoclonal antibodies (N=20,342 people with mild cognitive impairment or mild Alzheimer’s dementia) and concluded that any effect on memory decline or dementia severity was either nonexistent or well below the threshold considered clinically meaningful for patients. Key Findings …

Read more

+ Load more