Advances in Treatment-Resistant Depression: Causes, Symptoms, Interventions

Major depressive disorder (depression) is very common. It causes a lot of suffering and disability around the world. The good news is many people get better with medication, psychotherapy (talk therapy), or both. But for some people, depression just won’t go away even after trying multiple treatments. This is called treatment-resistant depression or TRD. Key …

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Electroconvulsive Therapy (ECT) Long-Term Effects: Grey Matter Changes in the Brain

A new study tracked changes in brain volume in depressed patients after electroconvulsive therapy (ECT or “electroshock therapy”). The study found that ECT led to increases in gray matter (brain tissue), which then decreased substantially over the next 2 years. The initial increases did not relate to improvement in depression symptoms. However, greater decreases 2 …

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Brain Reward System Dysfunction in Depression & Mental Disorders

Researchers explored how our brain’s reward system connects to depression and other common mental health problems like social anxiety and eating disorders. They found that a dampened reward response seems to follow, rather than precede, symptoms of depression and other disorders. This highlights the important role that blunted enjoyment plays in the persistence of mental …

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Link Between BMI (Body Weight) and Depression in Teens

Researchers explored the relationship between body weight and depression symptoms in teens and adults. They found a link between higher body weight and increased depression, especially among teens. Genetic factors appear to play only a small role. Key Facts: Teens who had higher body mass index (BMI) at age 12 were more likely to have …

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Deciphering Ketamine’s Role in Depression Treatment

Researchers are gaining exciting new insights into how the drug ketamine can rapidly treat symptoms of depression, including in people who don’t respond to other antidepressants. Key facts about ketamine for depression: Ketamine is an FDA-approved anesthetic that has been found to quickly improve mood in depressed patients, including those with treatment-resistant depression. It works …

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Modafinil vs. Citalopram for Major Depression: Equally Effective Treatment?

A new study published in the journal Mædica – a Journal of Clinical Medicine compared the antidepressant effects of modafinil versus citalopram for treating major depressive disorder (MDD). The medications were equally effective at reducing depressive symptoms over a 6-week treatment period. Key facts: 30 patients with MDD were treated with either modafinil or citalopram …

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Epigenetics & Depression Links: New Insights into Causes & Treatments

Major depressive disorder affects over 280 million people worldwide. While the causes are complex, new research is uncovering the role epigenetics plays in depression. Epigenetic changes can regulate how genes are expressed without altering the DNA sequence itself. These changes may explain why some people are more susceptible to depression and highlight new avenues for …

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SSRIs & Teen Brains: Unveiling the Role of DLPFC in Depression Recovery

A new brain imaging study provides insight into how antidepressants like selective serotonin reuptake inhibitors (SSRIs) may bring about symptom improvement in adolescents with major depressive disorder. The findings suggest that changes in a brain region involved in cognitive control may serve as markers of treatment response. Key Facts: Researchers used MRI scans to examine …

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A Lesser Known Risk of SSRIs: Lifelong Irreversible Sexual Dysfunction

A new study reveals that widely prescribed antidepressants may cause persistent erectile dysfunction in a small but significant number of male patients. Key Facts: The study found that serotonergic antidepressants like SSRIs and SNRIs triple the risk of erectile dysfunction (ED) compared to non-users. After stopping the antidepressants, 0.46% of patients (1 out of every …

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