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TL;DR: A 2026 biomarker analysis in Brain, Behavior, & Immunity – Health across antidepressant trials found that kynurenine pathway metabolites were elevated in inflammatory depression compared with non-inflammatory depression and healthy controls, while omega…
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TL;DR: A 2026 cross-sectional NHANES analysis in Depression and Anxiety found that urinary pyrethroid metabolite 3-PBA showed a dose-dependent association with depression, while female participants showed stronger associations for 3-PBA and 4F-3-PBA, while mal…
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TL;DR: A 2026 preprint deep brain stimulation biomarker study in medRxiv found that home-recorded electrophysiology biomarkers tracked stable depression recovery during SCC DBS, while the biomarkers helped distinguish recovery from nonspecific symptom fluctuat…
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TL;DR: A 2026 study in npj Mental Health Research found that a 308-person multimodal MRI study found treatment-resistant depression carried a distinct structure-function decoupling pattern, and machine-learning models separated TRD from non-resistant depressio…
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TL;DR: A 2026 randomized feasibility trial in JMIR Mental Health found both a structured AI therapy chatbot and ChatGPT reduced PHQ-9 depression scores versus assessment-only control, but neither AI condition improved anxiety significantly or beat the other. K…
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TL;DR: A 2026 study in Neuropsychopharmacology found that reward uncertainty, measured with functional MRI (fMRI), a brain-scan method, engaged different adolescent brain networks during waiting for a possible reward versus learning the outcome, with anxiety a…
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TL;DR: A 2026 study in JAMA Network Open found that a therapy built to restore reward and positive emotion outperformed a matched negative-affect therapy for adults with depression, anxiety, and severely low positive affect. Key Findings PAT beat the matched t…
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TL;DR: A 2026 study in The British Journal of Psychiatry found that serious mental illness labels shifted often in real-world psychiatric records: 64% of patients with schizophrenia, bipolar disorder, or severe major depression received multiple diagnoses over…
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TL;DR: A 2026 preprint UK Biobank neuroimaging study in medRxiv found that the comorbidity group showed widespread lower cortical volume, subcortical differences, and white matter microstructure alterations, while several alterations appeared unique to the chr…
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TL;DR: A 2026 study in Psychological Medicine found that stopping maintenance antidepressants did not meaningfully change facial emotion recognition over 12 or 52 weeks in adults with recurrent depression who were currently well. Key Findings Trial sample: The…
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