A new study examined whether metabolic biomarkers assessed through a high-throughput method are associated with future depressive symptoms. The results suggest the metabolites may not play a direct role in depression development. Key Facts: Researchers investigated associations between 121 metabolic measures and depressive symptoms at 7-year follow-up. Some metabolites showed tendencies for links with more …
A new meta-analysis found that continuous theta burst stimulation (cTBS), a novel form of brain stimulation therapy, does not appear to be more effective than sham (placebo) stimulation for treating symptoms of major depression. Key Facts: cTBS is a type of repetitive transcranial magnetic brain stimulation that aims to modulate activity in certain brain regions …
Eating foods rich in certain flavonoids may help lower the risk of experiencing depressive symptoms, suggests new research based on U.S. national health data. Key facts: Higher intakes of anthocyanidins, flavanones, flavones, and isoflavones were associated with lower odds of depressive symptoms after adjusting for confounders. There was an inverse association between total flavonoid intake …
An innovative study aims to assess the feasibility of patients self-managing transcranial direct current stimulation (tDCS) therapy for depression at home. This digitally-supported model could greatly expand access if proven safe, reliable and effective. Key Facts: tDCS uses scalp electrodes to deliver targeted electrical currents modulating brain activity Applied to prefrontal cortex, tDCS can have …
The European Medicines Agency (EMA) has updated its guidance on clinical trials for new depression treatments, with the goals of harmonizing standards across the EU and facilitating development of improved therapies. Key Facts: Depression is a highly disabling condition affecting many worldwide, which has been exacerbated by the COVID-19 pandemic Up to 2/3 of patients …
Electroretinography, a non-invasive retinal scanning technique, shows some promise for detecting suicidal behaviors based on changes in retinal cell signals. However, large scale studies are needed to determine its reliability. Key Facts: Electroretinography (ERG) measures electrical signals from retinal cells in response to light flashes to assess retinal health. ERG wave changes have been linked …
A new study conducted in rural South India has found that people whose parents are blood relatives (consanguineous marriage) have an increased risk of developing schizophrenia compared to the general population. Key Facts: Researchers recruited 120 patients with schizophrenia and 222 healthy controls from the same rural region in South India. 10.7% of patients with …
Kava kava, an herbal supplement made from the root of Piper methysticum, has gained popularity as an alternative treatment for anxiety and insomnia. A recent systematic review and meta-analysis re-examined kava kava’s effectiveness and safety for anxiety disorders. The authors concluded that kava kava is effective for short-term anxiety relief but long-term safety remains uncertain. …
Psychopathic individuals are known to commit a disproportionate amount of violence and crime. Yet the connections between psychopathy, intelligence and aggression are complex. A new study unpacks the links between these dangerous traits in men and women. Key Facts: Psychopathy was assessed using the Psychopathy Checklist: Screening Version which divides psychopathy into 4 facets – …
New research reveals that lower intelligence and poorer emotional control in adolescence are associated with an increased risk of suicidal thoughts and behaviors over the life course. However, while lower intelligence is linked to a consistently higher suicide risk into late middle age, the association between emotional control and suicide risk diminishes in strength over …
