TL;DR: A 2026 preprint in medRxiv reported that people living with dementia (PLwD) and carers were generally open to artificial intelligence (AI) support in structured medication reviews, but only when AI remained validated, transparent, secure, and subordinate to human clinical judgement. Key Findings 26-person qualitative sample: Researchers interviewed 12 people living with dementia and ran …
TL;DR: A 2026 study in Journal of Clinical Sleep Medicine found that after 12 months of watchful waiting for mild pediatric sleep-disordered breathing, only 13% of children progressed on polysomnography (PSG), an overnight sleep study, but 57% had persistent or worsening caregiver-reported symptoms. Key Findings 234 observed children: The analysis used the watchful-waiting arm of …
TL;DR: A 2026 preprint in medRxiv found that routine non-contrast brain computed tomography (CT) had a low acute-pathology yield in 291 emergency patients with new dizziness, while diabetes, ataxic gait, and headache marked higher odds of abnormal CT findings. Key Findings 291-patient cohort: The retrospective analysis included consecutive adults with new-onset dizziness who underwent non-contrast …
TL;DR: A 2026 medRxiv preprint used functional MRI (fMRI) and complex harmonics decomposition to study mindfulness-based cognitive therapy in 80 people with major depressive disorder, reporting post-treatment changes in whole-brain manifolds during rumination. Key Findings 80-patient trial sample: The preprint analyzed fMRI data from a randomized controlled trial in major depressive disorder. MBCT plus TAU: …
TL;DR: A 2026 Nature Communications paper introduced EmulatRx, a multi-agent AI framework that used real-world clinical data to help design target-trial-emulation workflows for acute and chronic diseases, including Alzheimer disease and Parkinson disease examples. Key Findings 20-trial evaluation: Researchers curated 20 clinical trials, with 10 acute-condition trials from MIMIC-IV and 10 chronic-disease trials from INSIGHT. …
TL;DR: A 2026 case-control study in Psychological Medicine linked major depressive disorder to faster blood-based transcriptomic aging and found that right-insula brain changes partly explained the depression association. Key Findings Transcriptomic aging was faster in depression: 141 people with major depressive disorder showed higher blood RNA-based aging acceleration than 134 healthy controls. The result strengthened …
TL;DR: A 2026 randomized trial in Molecular Autism found that a culturally adapted parent-implemented social communication program was linked to language, social-functioning, parent self-efficacy, and stress gains in Chinese-speaking autistic preschoolers, with no consistent advantage for therapist-led online groups over self-study across most outcomes. Key Findings Chinese preschoolers randomized: 112 autistic children aged 24-60 months …
TL;DR: A 2026 preprint in medRxiv found that poor sleep tracked faster biological aging across more than 64,000 adults, but twin and genetic analyses left the causal claim mixed rather than settled. Key Findings 64,000+ adults: Researchers tested sleep and aging biomarkers across five independent datasets spanning young, middle, and late adulthood. Poorer sleep quality: …
TL;DR: A 2026 randomized trial in BMC Anesthesiology found that adding an esketamine-adjuvanted stellate ganglion block to intraoperative esketamine plus dexmedetomidine reduced early postoperative sleep disturbance after gynecological laparoscopic surgery. Key Findings Sleep disturbance fell on day 1: Postoperative sleep disturbance affected 62.9% of patients in the stellate ganglion block group versus 83.2% in controls. …
TL;DR: A 2026 study in Autism Research found that autistic children with early speech delay needed longer sound gaps to detect timing changes, but detected smaller pitch-frequency changes than typically developing peers. Key Findings 21 autistic children were compared with 23 typically developing children: The autism group had early language delay and early autistic manifestations, …
