TL;DR: A 2026 medRxiv preprint found that stroke thrombectomy operators often had a preferred device technique, but that preference did not reliably match the technique with the highest first-pass reperfusion rate. Key Findings Stroke thrombectomy cohort: The single-center analysis included 1,405 acute ischemic stroke patients treated with mechanical thrombectomy from 2019 through 2024. 75% had …
TL;DR: Portable electroencephalography (EEG) recordings tracked perinatal anxiety most consistently in a preliminary medRxiv preprint, with delta power carrying the clearest longitudinal marker and alpha power appearing in visit-specific anxiety analyses. Key Findings First-trimester marker: Relative delta power before 16 gestational weeks was associated with third-trimester PHQ-9 depression and GAD-7 anxiety scores. Delta-anxiety link: Across …
TL;DR: A 2026 study in Translational Psychiatry combined positron emission tomography (PET) and functional MRI (fMRI) in alcohol use disorder and linked cerebellar hypermetabolism to disrupted fronto-cerebellar connectivity and poorer inhibition performance. Key Findings AUD-control sample: Researchers compared 27 people with severe alcohol use disorder (AUD) and 25 healthy controls. Multimodal imaging used: The study …
TL;DR: A 2026 study in eNeuro used intracranial electroencephalography (EEG), a recording method for brain electrical activity, during deep brain stimulation surgery and found that Parkinson’s disease and essential tremor patients with elevated depression symptoms had weaker corticostriatal alpha-beta reward signaling. Key Findings 30 DBS patients participated: The sample included 14 Parkinson’s disease patients and …
TL;DR: A 2026 randomized trial in Journal of the International Society of Sports Nutrition found that 12 weeks of combined interval resistance and aerobic training increased Maresin-1, an inflammation-resolving lipid mediator, in men with obesity, with the largest insulin-resistance improvement when training was paired with 200 mg/day fisetin. Key Findings 44 men completed the trial: …
TL;DR: A 2026 preprint in medRxiv analyzed plasma proteomics in Alzheimer’s disease and mild cognitive impairment and found that four continuous molecular axes described the data better than hard subtype labels. Key Findings 5,895-person AD/MCI sample: The discovery analysis used one record per participant from the Global Neurodegeneration Proteomics Consortium. 81.5% module-space variance: Four continuous …
TL;DR: A 2026 preprint in medRxiv warned that a standard Alzheimer’s disease biomarker-clock analysis can create a countdown paradox, where later biomarker-clock ages appear linked to faster mild cognitive impairment onset because of the way remaining time is calculated. Key Findings 100% false positives in simple null simulations: The standard countdown analysis rejected the null …
TL;DR: A 2026 review and activation-likelihood estimation study in European Journal of Pain found that the dorsolateral prefrontal cortex (dlPFC), a frontal control region, was repeatedly engaged in acute pain, chronic pain, and placebo analgesia, mainly across Brodmann areas 8, 9, and 46. Key Findings 138 studies included: The review screened 4810 deduplicated records and …
TL;DR: A 2026 study in Signal Transduction and Targeted Therapy engineered a modified inhibitory DREADD receptor called GRANPA so the over-the-counter antihistamine diphenhydramine could switch off targeted brain circuits and reduce seizure activity in mouse models. Key Findings Two added receptor mutations: The lead GRANPA receptor combined hM4Di with S85V and Y416F mutations to improve …
TL;DR: A 2026 randomized follow-up study in Maternal & Child Nutrition found no overall hair-cortisol difference at ages 9-11 after early-life small-quantity lipid-based nutrient supplementation, but children whose mothers had 0-5 years of schooling had lower cortisol if they received SQ-LNS. Key Findings No overall cortisol shift: Usable hair cortisol data from 680 children showed …
