Childhood Abuse Timing Linked to Hippocampus and Amygdala Emotion Responses

Childhood Abuse Timing Linked to Hippocampus and Amygdala Emotion Responses

TL;DR: A 2026 fMRI study in Molecular Psychiatry linked abuse before age 13 to stronger hippocampal responses during non-conscious negative emotion processing, while abuse during adolescence was linked to stronger amygdala responses during conscious emotion viewing. Key Findings Timing split the limbic response: The sample included 635 adults after exclusions and quality checks, including people …

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Open-Label Placebo Lowered Stress in Older Adults Over 3 Weeks

Open-Label Placebo Lowered Stress in Older Adults Over 3 Weeks

TL;DR: A 2026 randomized trial in International Journal of Clinical and Health Psychology found that older adults who knowingly took placebo pills for 3 weeks reported lower stress and performed better on Digit Span than controls. Key Findings Aging trial context: The trial randomized 90 healthy community-dwelling adults in Milan, ages 65 to 90, into …

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Postpartum Anxiety Linked to Pregnancy Inflammatory Biomarkers

Postpartum Anxiety Linked to Pregnancy Inflammatory Biomarkers

TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health linked composite inflammatory biomarkers during pregnancy and postpartum with postpartum anxiety symptoms, but the strongest associations ran in the unexpected direction of lower anxiety risk at higher biomarker levels. Key Findings 14,419 postpartum women were screened: Researchers calculated inflammatory biomarkers during the 2nd trimester, …

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Person-First Language May Reduce Forensic Mental Health Stigma

Person-First Language May Reduce Forensic Mental Health Stigma

TL;DR: A 2026 BJPsych Bulletin paper argues that person-first language in forensic mental health services may reduce stigma, social distance, and pessimism when it is used carefully rather than as a substitute for structural change. Key Findings Forensic mental health focus: The editorial examines labels used for people receiving care at the intersection of psychiatry …

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Parasite-Induced Neuroinflammation May Link Infection to Behavior

Parasite-Induced Neuroinflammation May Link Infection to Behavior

TL;DR: A 2026 review in the Journal of Neuroinflammation argued that several parasitic infections may affect behavior and cognition through converging microbiota, immune, barrier, and glial pathways. Key Findings Protozoa and helminths reviewed: The review covered neurotropic parasites such as Toxoplasma gondii, Plasmodium species, and Trypanosoma species, plus intestinal and tissue helminths. Five shared pathways: …

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OPHN1 Variant Linked to 24-Hour Cyclic Strabismus Without Intellectual Disability

OPHN1 Variant Linked to 24-Hour Cyclic Strabismus Without Intellectual Disability

TL;DR: A 2026 study in Scientific Reports identified a novel OPHN1 K306N variant in a boy with cyclic strabismus, linking a 24-hour eye-alignment rhythm to altered phosphoinositide binding without the intellectual disability usually associated with OPHN1 syndrome. Key Findings 8-year-old patient: A Japanese boy had cyclic esotropia, with left eye crossing in the morning and …

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ESVP PTSD Group Improved Social Function in Older Veterans

ESVP PTSD Group Improved Social Function in Older Veterans

TL;DR: A 2026 pilot randomized trial in Psychological Services found that a 9-session social-function group for older veterans with PTSD was feasible and acceptable, with stronger relationship gains than a support group in romantic and family functioning. Key Findings 36 randomized veterans: Participants were assigned to ESVP or a support-group comparison condition. 34 started treatment: …

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RF Capsulotomy and ITP-DBS Ranked Highest for Refractory OCD

RF Capsulotomy and ITP-DBS Ranked Highest for Refractory OCD

TL;DR: A 2026 study in Molecular Psychiatry found that radiofrequency capsulotomy and inferior thalamic peduncle deep brain stimulation were associated with the largest symptom improvements among surgical strategies for refractory obsessive-compulsive disorder. Key Findings 75 studies: The network meta-analysis included 75 studies, 1,259 patients, and 20 surgical strategies for refractory obsessive-compulsive disorder. Y-BOCS was primary: …

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HEALing Communities Study Found Coalition Factors Behind OUD Implementation

HEALing Communities Study Found Coalition Factors Behind OUD Implementation

TL;DR: A 2026 study in Implementation Science Communications found that high-performing HEALing Communities Study coalitions used representative membership, shared goals, data support, and communications campaigns to strengthen opioid-use-disorder service implementation. Key Findings 8 communities studied: Researchers selected the top-performing urban and rural waitlist-control communities from each of four HEALing Communities Study sites. 41 interviews analyzed: …

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Substance Use Disorders Affected 162.86 Million People Globally in 2021

Substance Use Disorders Affected 162.86 Million People Globally in 2021

TL;DR: A 2026 Journal of Global Health analysis of Global Burden of Disease 2021 data estimated that 162.86 million people had substance use disorders in 2021, with age-standardized rates down since 1990 but major inequality across sex, age, region, and development level. Key Findings 162.86 million cases: Global Burden of Disease 2021 estimates put worldwide …

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