Psychology

rTMS Plus Risperidone Improved Schizophrenia Cognitive and Aggression Scores

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rTMS Plus Risperidone Improved Schizophrenia Cognitive and Aggression Scores

TL;DR: A 2026 randomized controlled study in Pakistan Journal of Pharmaceutical Sciences found that adding 20 Hz repetitive transcranial magnetic stimulation (rTMS) to risperidone was linked with lower cognitive-factor and aggression scores after 4 weeks in schizophrenia patients. Key Findings Schizophrenia trial sample: The single-center trial randomized 80 patients, with 40 assigned to risperidone alone …

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Depression and Alcohol Polygenic Scores Improved Comorbidity Prediction

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Depression and Alcohol Polygenic Scores Improved Comorbidity Prediction

TL;DR: A 2026 study in Behavior Genetics found that combining major depressive disorder and alcohol use disorder polygenic scores improved prediction of their comorbidity in 7,965 Add Health participants, but added little for either condition alone. Key Findings Add Health dataset anchored the analysis: The study used 7,965 European, African, and Admixed American ancestry participants …

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Brief Yoga Raised Heart Rate but Not Cortisol in Stress Pilot

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Brief Yoga Raised Heart Rate but Not Cortisol in Stress Pilot

TL;DR: A 2026 randomized pilot study in JMIR Formative Research found that one brief yoga session did not significantly change salivary cortisol compared with quiet sitting, but it did raise heart rate during the active movement phase. Key Findings Yoga pilot sample: The pilot randomized 19 adults, with 10 participants assigned to a 24-minute yoga …

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Body Dysmorphic Disorder Symptoms Correlated With Perfectionism

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Body Dysmorphic Disorder Symptoms Correlated With Perfectionism

TL;DR: A 2026 meta-analysis in BMC Psychiatry found a moderate cross-sectional association between body dysmorphic disorder symptoms and perfectionism across 34 studies and 13,107 participants. Key Findings 34-study meta-analysis: The review pooled 34 studies with a total of 13,107 participants. Moderate main association: Body dysmorphic disorder symptoms correlated with perfectionism at r = .32, 95% …

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Betrayal Biased Social Inference Through Selective Observation

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Betrayal Biased Social Inference Through Selective Observation

TL;DR: A 2026 study in PLOS Computational Biology found that people overestimated an opponent’s competitiveness after betrayal, especially when they chose to watch the opponent instead of controlling their own avatar. Key Findings 62-person social task: 62 adults played a 2D prey-pursuit game with a computerized opponent whose hidden friendliness changed over time. Betrayal shifted …

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Neighborhood Disadvantage Linked to Faster Adolescent Cortical Decline

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Neighborhood Disadvantage Linked to Faster Adolescent Cortical Decline

TL;DR: A 2026 longitudinal study in Cerebral Cortex linked neighborhood disadvantage in childhood to lower adolescent cortical thickness and surface area, while better educational and health/environmental opportunities tracked greater MRI-estimated cortical thickness and surface area with slower developmental decline. Key Findings 11,639 adolescents: The analysis used ABCD Study neuroimaging data from 11,639 participants with at …

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Azocinoindole 5-HT2A Agonists Suppressed Mouse Head-Twitch Response

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Azocinoindole 5-HT2A Agonists Suppressed Mouse Head-Twitch Response

TL;DR: A 2025 study in Journal of the American Chemical Society used photochemistry to turn amino-acid-linked tryptamines into azocinoindoles that activated serotonin 5-HT2A signaling while suppressing the mouse head-twitch response. Key Findings C4 indole route: The method used light-induced cyclization to functionalize the indole ring at the C4 position. Amino-acid inputs: Amino acids were coupled …

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Nucleus Accumbens-Ventral Pallidum Pathway Regulated Rat Social Play

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Nucleus Accumbens-Ventral Pallidum Pathway Regulated Rat Social Play

TL;DR: A 2026 rat study in Brain Structure and Function found that ventral pallidum activity supports juvenile social play, while activating inhibitory nucleus accumbens inputs to the ventral pallidum reduced play behavior in both male and female rats. Key Findings Ventral pallidum inactivation: Bilateral muscimol microinfusion into the ventral pallidum reduced juvenile rat social play, …

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Physical Injury Methylation Signals Differed by Depression Status

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Physical Injury Methylation Signals Differed by Depression Status

TL;DR: A 2026 study in Biological Psychiatry: Global Open Science linked serious physical injury to recurrent major depression and found that injury-related DNA methylation patterns differed by depression status, with oxytocin, GABA, and synaptic-plasticity pathways standing out. Key Findings Large cohort anchor: researchers analyzed 4,308 Generation Scotland participants with or without a reported fracture from …

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NeuroMark SPECT Template Found Schizophrenia Perfusion Network Differences

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NeuroMark SPECT Template Found Schizophrenia Perfusion Network Differences

TL;DR: A 2026 medRxiv preprint introduced a 68-component NeuroMark template for single photon emission computed tomography (SPECT), a brain blood-flow imaging method, and found schizophrenia-related differences in cerebellar, subcortical, higher-cognition, visual, and triple-network perfusion patterns. Key Findings Template build: Researchers used blind independent component analysis on two large SPECT datasets of 5,001 and 5,000 scans …

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