Supplements

Probiotics Alter Clock Gene Expression in Depression to Improve Mood (2024 Study)

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Probiotic treatment may influence core clock gene expression and metabolites in individuals with major depressive disorder (MDD), potentially linking gut microbiota to circadian rhythms and mood regulation. Highlights: CLOCK Gene Expression: The expression level of the CLOCK gene significantly increased only in individuals receiving probiotic treatment, suggesting a direct impact of probiotics on circadian rhythms. …

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Omega-3 Fatty Acids & Souvenaid® May Slow Cognitive Decline in Alzheimer’s Disease (2024 Review)

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Omega-3 supplements and Souvenaid® show potential in slowing cognitive decline in Alzheimer’s patients, though the evidence remains inconclusive. Highlights: Cognitive Decline Reduction: The CDR scale showed a significant reduction in cognitive decline progression with Omega-3 supplementation (SMD = −0.4127, 95% CI: [−0.5926; −0.2327]). Mixed Cognitive Outcomes: 58% of studies reported positive cognitive effects from Omega-3 …

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Prebiotics, Probiotics, Synbiotics for ADHD May Improve Symptoms in Children (2024 Review)

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Probiotics and prebiotics show potential benefits in improving symptoms and quality of life in children with ADHD, but more extensive studies are needed to confirm these effects. Highlights: Positive Impact on Functioning: Lactobacillus rhamnosus GG (LGG) supplementation improved emotional, physical, social, and school functioning in children with ADHD. Reduction in Inflammation: Synbiotic 2000 reduced markers …

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Shexiang Baoxin Pills (SBP) May Reduce Depression & Improve Heart Function via Anti-Inflammatory Effect (2024 Rat Study)

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Shexiang Baoxin Pills (SBP) may help improve heart function and reduce depression in patients with acute myocardial infarction (AMI) by reducing inflammation. Highlights: Depression & Heart Disease Link: Patients with heart attacks often experience depression, which can worsen their heart condition. Study Purpose: This study tested the effectiveness of SBP, a traditional Chinese medicine, in …

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Omega-3 Fatty Acids & Depression vs. Genetics: EPA-to-DHA Ratio (2024 Study)

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Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), may reduce the risk of major depressive disorder (MDD), but causality remains uncertain due to potential pleiotropic mechanisms. Highlights: Genetic Evidence for Omega-3 & Depression: The study used two-sample Mendelian randomization to investigate the causality between genetically predicted omega-3 fatty acid levels and major depression, finding a protective …

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Oleacein (Rare Compound in Olive Oil) Exerts Anti-Neuroinflammatory & Antidepressant Effects via BDNF & TRKB (2024 Study)

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Oleacein, a compound found in extra virgin olive oil, shows potential as a natural treatment for depression and anxiety by reducing inflammation and boosting brain-derived neurotrophic factor (BDNF). Highlights: Oleacein & BDNF: Oleacein significantly increases BDNF expression, which is essential for brain health and neuroplasticity, both in human neuroblastoma cells and in the brains of …

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Omega 3 Fatty Acids May Improve Anxiety Symptoms (2024 Meta-Analysis)

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TLDR: Omega-3 supplementation shows potential for reducing anxiety symptoms, with the most significant improvement at a dose of 2 grams per day. Highlights: Dose-Dependent Effect: Each 1 gram per day of omega-3 supplementation led to a moderate decrease in anxiety symptoms, with the greatest improvement observed at 2 grams per day. Analysis: The meta-analysis included …

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Quercetin Alginate Nanogels Loaded with BDNF for Depression (2023 Study)

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TLDR: Quercetin-based alginate nanogels loaded with brain-derived neurotrophic factor (BDNF) can effectively cross the blood-brain barrier via intranasal delivery, providing a promising treatment for depressive disorders. Highlights: Nanogels: Quercetin nanogels protect BDNF from oxidative damage, exhibit rapid brain distribution, and significantly enhance bioavailability compared to oral administration. Efficacy: BDNF-Quercetin nanogels delivered via intranasal route show …

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Quercetin Health Benefits & Bioavailability: Medicinal Potential of a Plant Compound

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Quercetin is a plant flavonoid with a diverse range of pharmaceutical effects that make it a promising potential base for new medications. Key facts: It has anti-inflammatory, antioxidant, anti-tumor, and antiviral properties. Quercetin has low bioavailability on its own which limits its efficacy. Encapsulating quercetin in macromolecules like polymers increases bioavailability. Quercetin shows therapeutic promise …

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BPC-157 Peptide May Treat CNS Disorders: Stroke, Schizophrenia, Spinal Cord Injury

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The naturally occurring peptide BPC 157 shows potential to treat stroke, schizophrenia symptoms, and spinal cord injury in animal models. Key facts: BPC 157 rapidly counteracted stroke damage and led to full recovery of memory, coordination and movement in rats. The peptide alleviated schizophrenia-like symptoms and catalepsy in rodent models by modulating dopamine, glutamate and …

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